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Completed

NCT Number: NCT04228341

The Effect of Degree of Rice-polishing on Glycaemic Response

To investigate the effects of rice polishing on glycaemic and insulinaemic response in healthy Chinese male volunteers.

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Key information

Conditions

Diabetes Mellitus Body Weight Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

21 year–60 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Clinical Nutrition Research Centre

Singapore, 117599

About this study

There will be a total of 8 test session. Each session will last for 3.5 hours. At each test session, volunteers will be served with test meal and blood will be collected. After an overnight fast, subjects will visit the research center. Two fasting capillary blood samples will be collected via fingerprick. Following the fasting samples, subject will consume the test meals. Further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180 minutes after the ingestion of test meal. These samples will be used to analyses for whole capillary blood glucose. At every 30 minute interval, samples will be collected for analysis of capillary plasma insulin.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male
  • Chinese ethnicity
  • Age ≥21 and ≤ 60 years
  • Body mass index between 18.5 to 25 kg/m2
  • Normal blood pressure =<140/90 mmHg
  • Fasting blood glucose <6.0 mmol/L
  • In general good health

Exclusion criteria

  • Current smoker
  • Have any metabolic diseases (such as diabetes, hypertension etc)
  • Do not have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
  • Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
  • Have intolerances or allergies to any foods
  • Currently partake in sports at the competitive and/or endurance levels
  • Intentionally restrict food intake

Treatment and study plan

Glucose Reference 1

Other

50 g of glucose dissolved in 250 ml of water (First glucose control visit)

Glucose Reference 2

Other

50 g of glucose dissolved in 250 ml of water (Second glucose control visit)

Glucose Reference 3

Other

50 g of glucose dissolved in 250 ml of water (Third glucose control visit)

Brown rice

Other

Unpolished brown rice containing 50 g of available carbohydrate was cooked using a rice cooker (Toyomi) at a ratio of rice to water of 1: 2

3 % polished rice

Other

3% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2

6 % polished rice

Other

6% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2

9 % polished rice

Other

9 % polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2

20 % Polished rice

Other

White rice (20% polished rice), containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2.

Primary outcomes

  1. Glucose

    Time frame: Up to 180 minutes

    Whole capillary blood glucose will be measure using Hemocue analyser

Secondary outcomes

  1. Insulin

    Time frame: Up to 180 minutes

    Capillary plasma will be measure using Cobas analyser

Sponsors and collaborators

Lead sponsor

Singapore Institute of Food and Biotechnology Innovation

Other Gov

Registry information

Important dates

Study start
2019
Primary completion
2019
Study completion
2020
First posted
Jan 14, 2020
Registry last updated
Aug 20, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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