Department of Nutritional Sciences, University of Toronto
Toronto, Ontario, M5S 3E2, Canada
NCT Number: NCT02607007
This study investigates the effects of dairy breakfasts (2% cow's milk, 2% Greek yogurt, cheese) and a non-dairy breakfast (soy beverage) on satiety and post-meal blood glucose. Each participant will receive every treatment in this crossover design study.
Looking for future studies?
Notify Me60 year–70 year
All sexes
Interventional
Phase 1 / Phase 2
Toronto, Ontario, M5S 3E2, Canada
Regular consumption of dairy is associated with better body composition and lower incidences of type 2 diabetes and obesity. This may be due to dairy's ability to increase satiety and decrease post-prandial glycemia. However, most clinical studies have only investigated isolated dairy proteins (whey and casein) and the effects of whole dairy products, consumed as part of a meal, remain unclear. Additionally, the effect of dairy type and form remain to be further investigated. Therefore, this study will test the effects of dairy products when consumed with a high glycemic index breakfast on satiety and post-prandial glycemia.
Thirty healthy older males and females (60-70 years, BMI 18.5-30.0 kg/m2) will be recruited for the randomized, unblinded, crossover study. Participants will fast overnight, and at baseline will consume 1) 2% milk (250 mL), 2) soy beverage (250 mL), 3) plain 2% Greek yogurt (175 g), 4) cheddar cheese (30 g), or 5) water (250 mL - control). Treatments will be consumed along with 2 pieces of white toast with strawberry jam, except for the water control which will be consumed alone. All breakfast meals will be isocaloric and water will be given with the yogurt (75 mL) and cheese (220 mL) to compensate for fluid content. At 0 (baseline), 15, 30, 45, 60, 90, 120, 150, 180, (pre-meal period) and 210 minutes (post-meal period) blood will be collected for glucose analysis and subjective appetite ratings completed. Insulin will be analyzed every 30 minutes. Between 180-200 minutes, an ad libitum lunch will be provided to assess food intake.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Other names: 2% cow's milk, Neilsen Canada, White milk
Other names: White toast, Wonder Bread Canada
Other names: Pure strawberry jam (not seedless), Fruit jam, Smucker's
Other names: Mild cheddar cheese, Hard cheese, Armstrong Canada
Other names: Yogurt, Oikos, Danone Canada
Other names: Soy milk, Non-dairy alternative, So Good, Vanilla
Other names: Calorie-free control
Time frame: 0-210 minutes
Blood glucose (mmol/L) is measured using finger prick capillary blood samples
Time frame: 0-210 minutes
Subjective appetite ratings are obtained from four 100 mm visual analogue scale (VAS) questions assessing "Desire to Eat", "Hunger", "Fullness" and "Prospective Food Consumption". The average of all four VAS is calculated to obtain the average appetite score for statistical analysis.
Time frame: 0-210 minutes
Blood insulin (μU/mL) is measured using finger prick capillary blood samples
Time frame: 180-200 minutes
Food at an ad libitum lunch meal consisting of a dish of rice, meatballs, and tomato sauce will be weighed to determine food intake based on nutrition information provided by the manufacturers.
University of Toronto
Other
The Effect of Dairy and Non-dairy Breakfasts on Subjective Appetite Ratings, Food Intake, and Post-meal Glycemia in Healthy Older Adults
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT01809288
Behavior, Body Weight
Bethesda, Maryland, United States
View Trial DetailsNCT06697977
Body Weight, Diabetes
Amman, Jordan
View Trial DetailsNCT04392284
Body Weight, Cardiovascular Diseases
Birmingham, Alabama, United States
View Trial DetailsNCT04420650
Body Weight, Diabetes
Tübingen, Germany
View Trial Details