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Completed

NCT Number: NCT02491814

The Effect of Dairy and Non-dairy Alternatives on Satiety and Post-meal Glycemia in Healthy Young Adults

This study investigates the effects of commercially-available dairy (1% cow's milk and yogurt beverage) and non-dairy alternatives (almond and soy beverages) on satiety and post-meal blood glucose. Each participant will receive every treatment in this crossover design study.

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Key information

Age range

20 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Department of Nutritional Sciences, FitzGerald Building

Toronto, Ontario, M5S 3E2, Canada

About this study

Regular consumption of dairy is associated with better body composition and lower incidences of type 2 diabetes and obesity. This may be due to dairy's ability to increase satiety and decrease post-prandial glycemia. However, most clinical studies have only investigated isolated dairy proteins (whey and casein) and the effects of whole dairy products remains unclear. Additionally, as non-dairy alternatives are becoming more popular there is interest to see if they can elicit similar benefits as dairy. Therefore, this study will test the effects of commercially-available dairy and non-dairy beverages when consumed with cereal at breakfast time.

Thirty healthy young males and females (20-30 years, BMI 20.0-24.9 kg/m2) will be recruited for the randomized, unblinded, crossover study. Participants will fast overnight, and at baseline will consume 250 mL of 1% milk, soy beverage, almond beverage, yogurt beverage, or water with 54 g of Cheerios cereal. At 0 (baseline), 15, 30, 45, 60, 75, 90, 120 minutes (pre-meal period) 140, and 170 minutes (post-meal period) blood will be collected for glucose analysis and subjective appetite ratings completed. Insulin will be analyzed every 30 minutes and for the last two timepoints. Between 120-140 minutes, an ad libitum lunch will be provided to assess food intake.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy BMI (20.0 - 24.9 kg/m2)
  • Females with regular monthly menstrual cycles

Exclusion criteria

  • Diabetes
  • Fasting blood glucose higher than 5.8 mmol/L
  • Pregnancy
  • Medications
  • Smoking
  • Lactose intolerance or allergies to milk, soy, or almonds
  • Elite athletes
  • Those trying to lose or gain weight
  • Breakfast skippers and those on an energy-restricted diet
  • Score equal to or higher than 11 on Eating Habits Questionnaire

Treatment and study plan

1% M.F. Milk

Other

Other names: 1% cow's milk, Neilsen Canada

Yogurt Beverage

Other

Other names: Yop (Vanilla), General Mills

Soy Beverage

Other

Other names: Soy Milk, Silk Organic Original

Almond Beverage

Other

Other names: Almond Milk, Silk Original

Water

Other

Other names: Calorie-free control

breakfast cereal

Other

Other names: Cheerios, General Mills

Primary outcomes

  1. Blood Glucose

    Time frame: 0-170 minutes

    Blood glucose (mmol/L) is measured using finger prick capillary blood samples

  2. Subjective Appetite

    Time frame: 0-170 minutes

    Subjective appetite ratings are obtained from four 100 mm visual analogue scale (VAS) questions assessing "Desire to Eat", "Hunger", "Fullness" and "Prospective Food Consumption". The average of all four VAS is calculated to obtain the average appetite score for statistical analysis

Secondary outcomes

  1. Insulin

    Time frame: 0-170 minutes

    Blood insulin (μU/mL) is measured using finger prick capillary blood samples

  2. Food Intake

    Time frame: 120-140 minutes

    Food at an ad libitum pizza lunch will be weighed to determine food intake based on nutrition information provided by the pizza manufacturer

Sponsors and collaborators

Lead sponsor

University of Toronto

Other

Collaborators

  • Dairy Farmers of Canada

Registry information

Official study title

The Effect of Commercially-available Dairy and Non-dairy Alternatives When Consumed With a High Glycemic Cereal on Subjective Appetite Ratings and Post-meal Glycemia in Healthy Young Adults

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Jul 8, 2015
Registry last updated
May 12, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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