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NCT Number: NCT06712511

The Effect of Coffee on Energy Expenditure and Caffeine Metabolism

Obesity is a risk factor for chronic diseases, and improving energy expenditure is a way to prevent and treat obesity. The purpose of this project is to explore the relationship between the effect of coffee on energy expenditure and caffeine metabolism, which has important significance in the rational application of caffeine.

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Key information

Conditions

Healthy

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Shenzhen, Guangdong, 518055, China

Location status: Recruiting

Location contact

Huanan Zhang, Master

CONTACT

[email protected]

13371016641

About this study

The investigators will study the relationship between the effect of coffee on energy expenditure and caffeine metabolism. The investigators will recruit healthy participants. Participants will be forbidden to consume stimulant drinks such as coffee for 24 hours before the experiment. When the participants arrive at the lab on the day of the experiment, they will sign an informed consent form, a health history questionnaire and a daily coffee consumption questionnaire. The changes of drinking water/coffee on total energy expenditure (TEE), body temperature, heart rate, blood pressure, electrocardiogram, memory，cognition, sleep time and so on will be observed. The concentration of caffeine and its metabolites in the blood and urine will be measured by liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

：

  • Healthy adults.
  • Must be able to drink coffee.

Exclusion criteria

  • Diabetes.
  • Hypoglycemia.
  • Gout.
  • Osteoporosis.
  • Gastric ulcer.
  • Pancreatitis.
  • Intestinal obstruction.
  • Blood phobia.
  • Pathological hypo or hyper tension.
  • Impaired glucose tolerance.
  • Claustrophobia.
  • HIV,etc.

Treatment and study plan

Caffeine content

Other

Participants will drink the same volume of water or coffee, caffeine content is 2mg/kg by body weight.

Primary outcomes

  1. Total energy expenditure

    Time frame: 2 days

    Total energy expenditure will be measured by Chamber (OMNICAL).

  2. The concentration of caffeine and its metabolites in urine

    Time frame: 2 days

    The contents of caffeine and it's metabolites will be measured by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS ).

  3. The concentration of caffeine and its metabolites in serum

    Time frame: 1 day

    The concentration of caffeine and its metabolites in serum will be measured by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS ).

Secondary outcomes

  1. Body temperature

    Time frame: 2 days

    Body temperature of participants will be measured by body temperature patch (RIT-P02-MED).

  2. Electrocardiogram (ECG)

    Time frame: 2 days

    ECG of participants will be measured by Amu ECG belt, the changes in P wave, PR interval, PR segment, QRS wave group, J point, ST segment, T wave, QT interval, and U wave will be observe.

  3. Blood pressure

    Time frame: 2 days

    Systolic and diastolic blood pressure of participants will be measured by Omron digital sphygmomanometer.

  4. Height

    Time frame: The morning of the first day of the experiment, 5 mins

    Height will be measured by seca 217 stable stadiometer. Subjects wearing no shoes.

  5. Body weight

    Time frame: The morning of the first day of the experiment, 5 mins

    Fasting body weight will be measured by Bioimpedance Analysis (TANITA, MC-980).

  6. Fat mass

    Time frame: The morning of the first day of the experiment, 10 mins

    Fat mass will be measured by Magnetic Resonance Imaging (Shanghai united imaging, uMR 790 ).

  7. Fat free mass

    Time frame: on the morning of the experiment, 5 mins

    Fat free mass will be Bioimpedance Analysis (Tanita, MC-980).

  8. Heart rate

    Time frame: 2 days

    Heart rate will be measured by Polar heart rate belts.

  9. Hunger rating

    Time frame: 2 days

    Hunger score will be measured on (Visual Analogue Scale) VAS by a pen and a paper. According to the scores of each participant, the highest score was 100 % hunger rate, and hunger rate (%) at other time points will be obtained from hunger score × 100 % / the highest score.

  10. Memory and cognitive tests

    Time frame: The morning of the experiment, 60 mins

    Memory and cognitive tests will be tested by Cognitive Experiment Standard Toolbox (CEST).

  11. Physical activity

    Time frame: 7 days

    The physical activity of volunteers will be recorded by accelerometer (GT3XP-BTLE).

  12. Sleep duration

    Time frame: 2 days

    The sleep duration of volunteers will be recorded by polar watch.

  13. Waist circumferences

    Time frame: The morning of the first day of the experiment,10 mins.

    Waist circumferences will be measured using a whole body laser scanner (TG2000-F).

Study contacts

Contact information is provided by the study sponsor or research team.

Huanan Zhang, Master

CONTACT

[email protected]

13371016641

John R Speakman, PhD

CONTACT

[email protected]

15810868669

Sponsors and collaborators

Lead sponsor

Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences

Other

Registry information

Important dates

Study start
2024
Primary completion
2029
Study completion
2029
First posted
Dec 2, 2024
Registry last updated
Mar 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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