The Effect of Cocoa on Platelet Function Profiles in Patients

The effects of chocolate on cardiovascular health are still a matter of debate. It can potentially favor cardiovascular health through the antioxidative effects of cocoa ingredients, such as polyphenols (present in dark but not white chocolate).

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Key information

Conditions

Platelet Dysfunction

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The University of the West Indies

Saint Augustine, North, 000000, Trinidad and Tobago

About this study

Epidemiologic studies have shown inverse associations between dietary polyphenols (present in dark chocolate and cocoa) and mortality from coronary heart disease. However, the basis for this protective association is uncertain. Food polyphenols such as in cocoa reportedly have antioxidant properties and decrease platelet function in vitro. The goal of the present study was to investigate whether the beneficial antioxidant effect of polyphenol-rich cocoa can induce an improvement of endothelial and platelet function in patients with stable coronary artery disease with known platelet hyperreactivity.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with stable coronary artery disease.
Patients > 18y of age.

Exclusion criteria

Patients with T2DM.
Patients who already ingest any cocoa-based products.

Treatment and study plan

cocoa

Dietary Supplement

2-week, once-daily 70%, 50g cocoa bar manufactured by The UWI Cocoa Research Institute (14 bars)

Primary outcomes

P2Y12 Reaction Units

Time frame: 2-weeks

P2Y12 Reaction Units pre- and post-Cocoa

Sponsors and collaborators

Lead sponsor

The University of The West Indies

Other

Registry information

Official study title

The Effect of Cocoa on Platelet Function Profiles in Patients With Stable Coronary Artery Disease in Trinidad and Tobago: The ECLAIR Study

Acronym: ECLAIR

Important dates

Study start: 2020
Primary completion: 2022
Study completion: 2022
First posted: Sep 18, 2020
Registry last updated: Aug 25, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed