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Completed

NCT Number: NCT00644657

The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization

This study will explore the effect of clopidogrel on coated-platelets in patients who are given a loading dose before diagnostic catheterization or percutaneous coronary intervention. We hypothesis that clopidogrel will reduce the percentage of platelets that are coated and therefore more hypercoagulable.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Chest Pain Coronary Disease Heart Diseases Myocardial Ischemia Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Vascular Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

VA Medical Center, 1F187

Oklahoma City, Oklahoma, 73104-5076, United States

About this study

Platelet activity will be determined by light transmission aggregometry at baseline, after a 300 mg dose of clopidogrel and after the catheterization and/or angioplasty procedure. The change in the percentage of platelets that are coated platelets will be determined.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients given clopidogrel loading dose before scheduled catheterization or percutaneous intervention

Exclusion criteria

  • Acute coronary syndrome
  • Unable to tolerate clopidogrel

Treatment and study plan

clopidogrel

Drug

All subjects will receive a 300 mg loading dose

Other names: Plavix

Primary outcomes

  1. The Percentage of Coated Platelets After the Administration of Clopidogrel in Patients Undergoing Cardiac Catheterization and/or Angioplasty

    Time frame: 24 hours after the administration of clopidotrel

    The percentage of platelets that are collagen coated after the administration of clopidogrel.

Secondary outcomes

  1. The Percentage of Coated Platelets After Coronary Angiography and/or PCI

    Time frame: 6 hrs after procedure

    The percentage of coated platelets 24 hours after coronary angiography and/or PCI

Sponsors and collaborators

Lead sponsor

University of Oklahoma

Other

Registry information

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Mar 27, 2008
Registry last updated
Oct 7, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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