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NCT Number: NCT01968525

The Effect of Chronic Anemia on Safety Period of Tracheal Intubation in Gynecology Patients

1. Every individual receiving a general anesthetic is at potential risk for developing a ''cannot intubate-cannot ventilate'' situation following anesthetic induction. 2. Building up of oxygen reserves assumes great significance as this provides a longer duration of non-hypoxic apnea should one be faced with an unanticipated difficult airway. 3. The main physiological functions of red blood cell hemoglobin are to deliver oxygen to the peripheral tissues. 4. During anemia, a reduction in blood oxygen content occurs as a result of reduced Hb while arterial oxygenation and oxyhemoglobin saturation remain high. 5. Previous studies about the duration of non-hypoxic apnoea focus on methods to improve the safety period of tracheal intubation. 6. To our knowledge, there is no literature about the duration of non-hypoxic apnoea of anemia patients. 7. The aim of this study was to assess the effect of chronic anemia on the duration of non-hypoxic apnoea during induction of anaesthesia.

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Key information

Conditions

Chronic Anemia Anemia Hematologic Diseases Hemic and Lymphatic Diseases

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Fudan university

Shanghai, Shanghai Municipality, 200090, China

About this study

After breathing for 3 minutes, anesthesia induction was conducted. The endotracheal tube position was confirmed after anesthesia induction. Patients were left apneic with the endotracheal tube open to room air. The non-hypoxic apneic period was recorded as the time (in seconds) taken for the drop in pulse saturation to 90% or an apneic period of 10 min elapsed, whichever was earlier.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients scheduled to undergo general anesthesia
  • American Society of Anesthesiologists Performance Status 1-2
  • adults

Exclusion criteria

  • Individuals with significant cardiorespiratory or cerebrovascular disease,
  • difficult intubation
  • history of epilepsy
  • body mass index >25 kg/m2,
  • and those who had smoking history in past 6 months

Treatment and study plan

pre-oxygen

Biological

3 min of preoxygenation before anesthesia induction.

Primary outcomes

  1. duration of non-hypoxic apnoea

    Time frame: up to 6 months

Sponsors and collaborators

Lead sponsor

Fudan University

Other

Registry information

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Oct 24, 2013
Registry last updated
Oct 24, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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