The Effect of Channa Striata and Curcuma Supplementation on Nutritional Status, Interleukin-6 Levels, and Quality of Life in Patients With Breast Cancer.

Breast cancer is frequently accompanied by chronic inflammation, malnutrition, and reduced quality of life, all of which may compromise treatment response and clinical outcomes. Nutritional interventions with immunomodulatory and anti-inflammatory properties have the potential to improve these conditions. Channa striata is rich in high-quality protein, albumin, and essential amino acids that support nutritional recovery and tissue repair, while Curcuma contains curcumin, a bioactive compound with well-established anti-inflammatory and antioxidant effects. This study aims to evaluate the effect of combined Channa striata and Curcuma supplementation on nutritional status, serum interleukin-6 (IL-6) levels, and quality of life in patients with breast cancer undergoing treatment. The findings are expected to provide evidence for the use of this nutritional supplementation as a complementary strategy to improve clinical outcomes, reduce systemic inflammation, and enhance the overall well-being of breast cancer patients.

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Key information

Conditions

Breast Cancer Breast Diseases Breast Neoplasms Inflammation Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Skin Diseases Skin and Connective Tissue Diseases

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Nutrition Department

Medan, North Sumatera, Indonesia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Female patients with breast cancer aged ≥18 years who were undergoing chemotherapy.
Patients with a body mass index (BMI) of 18-29 kg/m².
Patients currently receiving chemotherapy for breast cancer.
Patients with serum albumin levels of 2.0-3.5 g/dL.
Patients who were able to consume oral food and were willing to participate in the study by providing written informed consent.

Exclusion criteria

Patients with chronic kidney disease, renal failure, or kidney infection.
Patients with a known allergy to fish or Channa striata (snakehead fish) albumin-derived products.
Patients receiving other protein or amino acid supplements during the study period.
Patients who were non-compliant or discontinued the intervention before completion of the study.

Treatment and study plan

channa striata and curcuma

Dietary Supplement

Participants in the intervention group received oral supplementation consisting of 5 g of Channa striata and 250 mg of Curcuma daily for one month, while participants in the control group received a maltodextrin placebo daily for the same duration.

Maltodextrin (Placebo)

Dietary Supplement

Participants in the control group received a placebo consisting of maltodextrin daily for one month.

Primary outcomes

Nutritional status

Time frame: baseline post intervention 4 weeks

This study evaluated changes in BMI, following one month of Channa striata and Curcuma supplementation.

Secondary outcomes

interleukin - 6

Time frame: Baseline and 1 month after intervention

Change in serum interleukin-6 (IL-6) concentration from baseline to 1 month after daily supplementation with Channa striata and Curcuma in patients with breast cancer undergoing chemotherapy

Study contacts

Contact information is provided by the study sponsor or research team.

Damayanti Tridah Ayu

CONTACT

[email protected]

628116816444

Sponsors and collaborators

Lead sponsor

DINA KEUMALA SARI

Other

Registry information

Acronym: CCBreast

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2027
First posted: Jul 23, 2026
Registry last updated: Jul 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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