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Completed

NCT Number: NCT06770166

The Effect of Chamomile on Healing After Tooth Extraction

After impacted wisdom tooth extraction, patients frequently complain of pain, edema, and limited mouth opening. After the procedure, patients are routinely recommended to use chlorhexidine and physiological serum-based mouthwashes. The antibacterial and anti-inflammatory effects of warm chamomile tea have been reported in the literature. In addition, the neuroprotective, antiallergic, antioxidant, antiseptic and spasmolytic properties of chamomile have been reported. The aim was to compare the effects of these gargles in terms of pain, mouth opening, burning sensation in the mouth, edema, and discoloration of the tongue and teeth.

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Key information

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Istanbul Medipol University Dental School

Istanbul, Unkapani, 34083, Turkey (Türkiye)

About this study

The study was planned to be applied to 120 patients, 40 in each group. In the ASA 1 group, the mouth opening of the patients was recorded before the tooth extraction procedure. Impacted teeth were extracted using Ultracain D-S Forte (Articaine HCl: 40mg/ml, Epinephrine HCl: 0.012 mg/ml) as a local anesthetic. Dental units were prepared under sterile conditions. The patients were covered with a sterile drape. The lower wisdom tooth was extracted with open (surgical) extraction. The mucoperisoteal flap was lifted with a number 15 surgical scalpel, and the tooth was extracted using round and fissure-tipped steel burs with a handpiece. After tooth extraction, if there was granulation tissue in the extraction socket, it was curetted and irrigated with physiological serum [sodium chloride: 0.009 g/ml, sodium 154 (mEq/I), chloride 154 (mEq/I)]. After bleeding control, patients were given written and verbal postoperative advice. Antibiotics and analgesics were prescribed to patients, chlorhexidine gargle was recommended to 30 patients, saline gargle to 30 patients, and chamomile tea gargle to 30 patients. Patients were given VAS pain scores, numbered 0-10, to record for 7 days after extraction. Patients were called back to the clinic on the 2nd and 7th days after tooth extraction to assess pain, burning sensation and color change in the tongue, mouth opening, and edema. Sutures were removed on the 7th postoperative day.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • American Society of Anesthesiologists (ASA) physical status I patients,
  • did not have the medical history of being allergic to local anesthesia
  • did not have the medical history of being allergic to CHX,
  • did not have acute infection at the tooth area
  • absence of any pathology at the area.

Exclusion criteria

  • Participants with medically compromised condition,
  • pregnant females
  • smokers

Treatment and study plan

Physiological serum mouthwash

Other

Physiological serum contains sodium chloride : 0.009 g/ml, sodium 154 (mEq/I), chloride 154 (mEq/I)].

Chlorhexidine mouthwash

Other

Chlorhexidine mouthwash contains 0.12% chlorhexidine digluconate and 0.15% benzydamine hydrochloride.

Chamomile mouthwash

Other

Chamomile mouthwash contains 10% chamomile in physiological serum.

Primary outcomes

  1. Patients pain value

    Time frame: The patient marked the pain value every day for one week.

    visual analog scale (VAS) is used for pain assessment. The patient marked the pain value on the 0-10 visual analog scale.

  2. maximum mouth opening

    Time frame: maximum mouth opening was measured preoperatively, postoperative 3rd and 7th days.

    maximum mouth openin were measured with the reference of 11 and 41 teeth. are used for interincisal distances

Sponsors and collaborators

Lead sponsor

reyhansaglam

Other

Registry information

Official study title

The Effect of Chamomile on Healing After Tooth Extraction: a Retrospective Randomized Controlled Trial

Important dates

Study start
2019
Primary completion
2024
Study completion
2024
First posted
Jan 13, 2025
Registry last updated
Jan 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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