NCT Number: NCT03950531
The Effect of Bronchiectasis on the Exacerbation and Mortality in COPD
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways and lungs that develops against harmful particles or gases with exacerbations. Coexistence of bronchiectasis with COPD may lead to worsening of the functional parameters as well as alteration of the microbiological pattern in exacerbations and may negatively affect the exacerbation result parameters.
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Notify MeKey information
Conditions
Age range
40 year–70 year
Sex eligibility
All sexes
Study type
Observational
About this study
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the airways and lungs that develops against harmful particles or gases with exacerbations. COPD exacerbations are characterized by worsening of dyspnea, coughing and expectoration. Exacerbations requiring hospitalization are the main cause of morbidity and mortality in COPD. Bronchiectasis is the irreversible extension of the bronchi. Usually follows with chronic sputum cough, airway obstruction and recurrent infection episodes. The association of bronchiectasis and COPD has long been known and its incidence is in the range of 30-50%. Coexistence of bronchiectasis with COPD may lead to worsening of the functional parameters as well as alteration of the microbiological pattern in exacerbations and may negatively affect the exacerbation result parameters.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Patients who underwent thoracic tomography in the last year according to index exacerbation date were included in the study
Exclusion criteria
- Cases that mimic COPD exacerbation (pneumonia, pulmonary thromboembolism, pulmonary congestion, pneumothorax, pleural effusion, lung malignancy, asthma, asthma-COPD overlap syndrome) and patients admitted to the intensive care unit were excluded from the study.
Treatment and study plan
Primary outcomes
-
Charlson Comorbidity Index
Time frame: 1 hour
Comorbidity scores
Secondary outcomes
-
Spirometry
Time frame: 1 hour
Pulmonary function measurement
Sponsors and collaborators
Lead sponsor
Ministry of Health, Turkey
Other Gov
Registry information
Official study title
The Effect of Bronchiectasis on the Exacerbation and Mortality of Chronic Obstructive Pulmonary Disease
Important dates
- Study start
- 2010
- Primary completion
- 2014
- Study completion
- 2017
- First posted
- May 15, 2019
- Registry last updated
- May 17, 2019
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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