Skip to main content
OpenTrials
Completed

NCT Number: NCT02161042

The Effect of Blood Transfusion on Endothelial Function

Blood transfusion is often used to treat patients with Anemia. The period of storage of blood products prior to use for transfusion may vary. Prolonged storage of blood products may result in changing their biochemistry.

This study aims to look into whether the transfusion of "old" blood, which is stored for more than 7 days, as compared to the transfusion of "Fresh" blood, which is stored for less than 7 days, will affect endothelial function.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

MDS Anemia Hematologic Diseases Hemic and Lymphatic Diseases

Age range

18 year–95 year

Sex eligibility

All sexes

Study type

Observational

Primary location

London Health Sciences Centre

London, Ontario, N6A5A5, Canada

About this study

Endothelial function assessed pre and post transfusion. The EndoPAT uses a unique bio-sensors that are placed on the fingertips to measure pressure. The test takes about 20-25 minutes. During the procedure the participant will have biosensors placed on the index finger of each hand. The nondominant arm will have a blood pressure cuff applied with sufficient pressure for five minutes. At the end of the test the device will provide a reading that assesses the level of endothelial function/dysfunction.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age is > 18 years
  • Need recurrent blood transfusion

Exclusion criteria

  • Latex Allergy
  • Life expectancy is less than 6 months
  • History or evidence of drug or alcohol abuse in the last 12 months
  • Any medical condition that will place the participant at a higher risk if they participate in the study

Treatment and study plan

Primary outcomes

  1. Endothelial function

    Time frame: Change in endothelial function compared to baseline. Test is done 15 minutes prior to transfusion and 30 minutes post blood transfusion. The test is repeated when patient received another blood transfusion. The results of the change are compared.

    The function of the blood vessels will be assessed with the EndoPAT device. This test is done 15 minutes prior to the transfusion and again 30 minutes post the transfusion. Patients that will receive both fresh and old blood will be included.

Sponsors and collaborators

Lead sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Other

Registry information

Important dates

Study start
2011
Primary completion
2016
Study completion
2016
First posted
Jun 11, 2014
Registry last updated
Oct 5, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.