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Completed

NCT Number: NCT00382551

The Effect of Beer, Red Wine and Fruit Juice on Blood Vessel Function in Persons With Cardiovascular Disease

To study the effect of red wine, beer and fruit juice on endothelial function in patients with coronary Heart disease.

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Key information

Conditions

Coronary Heart Disease Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

30 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Department of Cardiology, Aalborg Hospital, Science and Innovation Center

Aalborg, 9000, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men or postmenopausal women with stable coronary heart disease
  • Coronary heart disease should be verified by coronary angiography with at least 50% stenosis in at least one coronary vessel.

Exclusion criteria

  • Patients with myocardial infarction within the last tree months
  • Persons with a present or earlier alcohol abuse
  • Persons with a present or earlier drug abuse
  • Person with malign disease
  • Persons, that we consider unsuitable to carry through the examines.

Treatment and study plan

Moderate daily consumption of Red wine

Behavioral

Moderate daily consumption of beer

Behavioral

Moderate consumption of fruit juice rich in polyphenolics

Behavioral

Primary outcomes

  1. Changes in flow-mediated vasodilation after 2 weeks intervention compared with baseline

Secondary outcomes

  1. Lipid status after 2 weeks intervention compared with baseline

  2. Effects in Coagulation factors after 2 weeks intervention

  3. Effects on markers of inflammation after 2 weeks intervention

  4. Effects on markers of endothelial function after 2 weeks intervention

  5. Changes in the overall antioxidant activity in plasma after 2 weeks intervention

Sponsors and collaborators

Lead sponsor

Aalborg University Hospital

Other

Registry information

Official study title

The Effect of Alcohol and Polyphenolic Compounds on Endothelial Function

Important dates

Study start
2006
First posted
Sep 29, 2006
Registry last updated
Jan 30, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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