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Completed

NCT Number: NCT04627220

The Effect of Arterial Oxygen Parameters on Antioxidant Parameters

We aimed to measure the changes in your blood values caused by different but safe oxygen values used by us during your heart surgery under laboratory conditions.

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Key information

Conditions

Cardiovascular Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital

Bursa, 60160, Turkey (Türkiye)

About this study

Hyperoxia is often preferred due to the risk of tissue hypoxia that may develop in cardiac surgery. It is thought that with hyperoxemia, ischemia reperfusion damage increases, microcirculation is impaired and tissue oxygenation is impaired.Oxidative damage occurs in cases of increased oxidative stress and impaired antioxidant balance.It was aimed to investigate oxidative damage by recording modified albumin and thiol disulfide in blood simultaneously by recording arterial oxygen levels at determined times during cardiac surgery.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient scheduled for cardiac surgery
  • ASA>3
  • Aged 18-75 years

Exclusion criteria

  • those with valvular disease
  • EF<%40
  • BMI>40 kg/m2
  • presence of arrhythmia that impairs hemodynamics
  • previous history of cerebrovascular
  • diagnosed with end-stage organ failure

Treatment and study plan

taken venous sample

Diagnostic Test

Venous blood samples taken during the operation and at the 48th hour after the operation will be examined after appropriate procedures.

Primary outcomes

  1. assessment of oxidative damage

    Time frame: 48 hours after operation

    To measure the degree of oxidative damage in the patient's blood at different oxygen values used in cardiac bypass surgeries with thiol disulfide homeostasis and ischemia-modified albumin at times determined.

Sponsors and collaborators

Lead sponsor

Bursa Yuksek Ihtisas Training and Research Hospital

Other Gov

Registry information

Official study title

The Effect of Arterial Oxygen Levels on Thiol Disulfide Homeostasis and Ischemia Modified Albumin in Coronary Artery Bypass Surgery

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Nov 13, 2020
Registry last updated
Nov 13, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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