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OpenTrials
Completed

NCT Number: NCT03793777

The Effect of Aronia Melanocarpa Extract on Cognitive Function

There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance . Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance.

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Key information

Conditions

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Maastricht University

Maastricht, Limburg, 6229ET, Netherlands

About this study

There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance. Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance. The product in this study is aronia melanocarpa which contains polyphenols. A limited number of clinical studies have already been carried out to see the effect of similar products on cognitive functioning. However, these studies have often been done in older study populations or over a longer period of time. In this study, in healthy adolescents (ages between the 18-35 and with a BMI between 18.5 and 30), the investigators want to test the short term (7 days) effect of aronia melanocarpa extract on cognitive functioning. The investigators will also test the effect of supplementation on the particpant's mood, vascular function, blood biomarkers, retinal vasculature, and subjective cognition.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy young adults: ages between 18 and 35
  • BM between 18.5-30 kg/m2

Exclusion criteria

  • Current use of (antioxidant) dietary supplements and not willing to quit for the duration of the study duration
  • Pre-existing or history of neurological illness
  • High blood pressure (>140 systolic and/or >90 diastolic mmHg)
  • Use of medication that might have influence on endpoints (e.g. antidepressant)
  • Known pregnancy or lactation
  • Food allergy to the study product
  • Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study, to be decided by the principle investigator, in the 180 days prior to the study
  • Abuse of products (> 20 alcoholic consumptions per week and drug usage)
  • Participation in a scientific intervention study which may interfere with this study in the 180 days prior to this study

Treatment and study plan

Aronia

Dietary Supplement

daily supplementation

Placebo

Dietary Supplement

daily supplementation

Primary outcomes

  1. Cognitive function

    Time frame: After 7 days of supplementation

    CANTAB

Secondary outcomes

  1. Mood

    Time frame: After 7 days of supplementation

    VAMS

  2. Biomarkers in blood and saliva

    Time frame: After 7 days of supplementation

    BDNF & cortisol

  3. Vascular function

    Time frame: After 7 days of supplementation

    SBP & DBP, PWA & PWV

  4. Microvasculature

    Time frame: After 7 days of supplementation

    Fundus photography

  5. Subjective cognition

    Time frame: After 7 days of supplementation

    Cognitive Failures Questionnaire

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Collaborators

  • BioActor B.V.

Registry information

Official study title

The Effect of Short-term Aronia Melanocarpa Extract Supplementation on Cognitive Function in Healthy Young Adults

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Jan 4, 2019
Registry last updated
Sep 5, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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