The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery

Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx.

The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.

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Key information

Conditions

Ischemia Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Konkuk University Medical Center

Seoul, 143-729, South Korea

About this study

The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order.

Preoperation (immediate before anesthesia induction)
Immediate before tourniquet off
5 min after tourniquet off
PACU
postoperative 6 hours
postoperative 24 hours

Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients who was planned to undergo knee surgery.

Exclusion criteria

age < 20 years old
history of previous cancer
history of previous peripheral vascular disease
Emergency surgery

Treatment and study plan

Propofol group

Drug

Patient will be anesthetized by using propofol infusion during operation.

Other names: Propofol

Desflurane group

Drug

Patient will be anesthetized by using desflurane inhalation during operation.

Other names: Desflurane

Primary outcomes

Syndecan-1

Time frame: Preoperative time, Immediate before tourniquet off,5 min after tourniquet off,PACU, postoperation after 6hours, postoperation after 24hours

change of level of syndecan-1 (scores range from 0 to 100)

Sponsors and collaborators

Lead sponsor

Konkuk University Medical Center

Other

Registry information

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2020
First posted: Apr 29, 2016
Registry last updated: Feb 28, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed