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Completed

NCT Number: NCT05779748

The Effect of an Acute Bout of Exercise on Pain Sensitivity and Clinical Pain in Adults With Chronic Low Back Pain

The goal of this interventional study is to investigate the efficacy of an acute bout of exercises on pain sensitivity (primary aim) and clinical pain intensity (secondary aim) among adults with Chronic Low Back Pain. The following question will be answered in this research Q1: Is acute bout of exercise effective in reducing pain among adults with Chronic Low Back Pain?

Participants who agree to participate and sign the informed consent will be randomized to one of three groups:

Group 1: Isometric exercise with neutral language and no verbal suggestion consisting of 1 rep of wall squat, 3 min or to volitional fatigue at 100° knee angle;(n=30).

Group 2: Isometric exercise with neutral language and no verbal suggestion consisting of 3 reps of wall squat, 3 min or to volitional fatigue at 100°degree knee angle, 30-sec rest between rep, ;(n=30).

Group 3 (Control group): true control (do nothing);(n=30).

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Key information

Conditions

Chronic Low-back Pain

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

King Abdullah Hospital

Bisha, Saudi Arabia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged 18 years or older; and
  • diagnosed with chronic non-specific LBP (lasting for more than 12 weeks).
  • Able to perform physical therapy exercises.

Exclusion criteria

  • pregnancy.
  • patients who have neurological compromise (e.g., cauda equine syndrome or spinal nerve compromise).
  • Patients who have spinal pathologies (e.g., fracture, ankylosing spondylitis)
  • Uncontrolled diabetic.
  • who has any history of heart disease (e.g., myocardial infarction, embolism)
  • Orthopaedic impairment (e.g., balance problems)

Treatment and study plan

Single bout of exercise

Other

isometric wall squat at a knee joint angle of 100 degrees. Instruct participant to place their back against the wall with feet positioned parallel and spaced shoulder-width apart. Lower themselves down until they reached a knee joint angle of 100 degrees. Measure knee joint angle by placing a goniometer on the lateral epicondyle of the knee, in line with the femur whilst the anchor arm was in line with the lateral malleolus.

Primary outcomes

  1. Pain pressure threshold

    Time frame: [ Time Frame: Change from pre-intervention (baseline) compared to post-intervention (immediately after session) ]

    The pain will be measured using digital pressure algometer, FDX®️ (Wagner instrument, Greenwich, USA). All trials will be conducted on forearm, lumbar spine and calf sites. There will be at least 20 sec rest before an individual site is tested again. Two trials will be performed at each site. The raw values of each test will be recorded.

    Because we are testing repeated times, we will use a marker to mark the location of each test site to ensure consistency in location.

    Algometer must be positioned perpendicular to the measurement site for all trials.

Secondary outcomes

  1. Pain intensity

    Time frame: [ Time Frame: Change from pre-intervention (baseline) compared to post-intervention (immediately after session) ]

    It will be assessed using Visual Analogue Scale (VAS; 0-10). A rating of zero means that participant don't currently have pain at the low back. A rating of ten on this scale means that the pain at low back is the worst pain. So, the higher the number on this scale means the higher the pain intensity participant is experiencing.

Sponsors and collaborators

Lead sponsor

Taif University

Other

Collaborators

  • King Abdullah Hospital

Registry information

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Mar 22, 2023
Registry last updated
Aug 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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