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Completed

NCT Number: NCT00857909

The Effect of Amiloride and Spironolactone in Healthy Persons

This study will investigate whether retaining potassium in the body will lead to changes in blood pressure and changes in blood and urine samples.

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Key information

Conditions

High Blood Pressure Cardiovascular Diseases Hypertension Vascular Diseases

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Medical Research

Holstebro, 7500, Denmark

About this study

The purpose is to measure the effect of amiloride and spironolactone on:

  • Renal function (GFR, u-AQP2, u-ENaCβ, u-cAMP, u-PGE2, CH20, FENa, FEK),
  • Pulsbewave velocity, augmentation index and central blood pressure,
  • Vasoactive hormones (PRC, AngII, Aldo, AVP, ANP, BNP and Endot), and
  • Ambulatory blood pressure

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • Non-smokers

Exclusion criteria

  • Smoking
  • Under medical treatment

Treatment and study plan

Amiloride

Drug

1 tablet twice a day

Spironolactone

Drug

1 tablet twice a day

Placebo

Drug

Placebo

Placebo and spironolactone

Drug

5mg twice daily

Primary outcomes

  1. Blood pressure

    Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Regional Hospital Holstebro

Other

Registry information

Official study title

The Effect of Amiloride and Spironolactone Measured on Cardiovascular and Kidney Related Variables in Healthy Subjects in a Double-blinded, Randomised, Placebo-controlled, Cross-over Study

Acronym: SPAS

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Mar 9, 2009
Registry last updated
Jul 8, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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