Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07289750

The Effect of Alogliptin Combined With Actoplus Met on Glucose and Lipid Metabolism and Pancreatic Function in Patients With T2DM Complicated With MAFLD

To compare the efficacy and safety of the combination of alogliptin and actoplus met with that of actoplus met alone in improving the glucose and lipid metabolism and pancreatic function in T2DM patients complicated with MAFLD.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

T2DM MAFLD

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of T2DM
  • Clinical diagnosis of MAFLD
  • HbA1c: 6.5-9.5%
  • BMI: 19-35 kg/m2
  • No hypoglycemic drugs or insulin have been used within half a year

Exclusion criteria

  • Severe infections, surgeries and other emergency
  • Other types of diabetes
  • Severe cardiovascular, brain, liver and kidney disorders
  • Malignant tumor

Treatment and study plan

alogliptin and actoplus met

Drug

combination of alogliptin and actoplus met

actoplus met

Drug

actoplus met

Primary outcomes

  1. hemoglobin A1c

    Time frame: 6 months of treatment

Sponsors and collaborators

Lead sponsor

The Fourth Affiliated Hospital of Zhejiang University School of Medicine

Other

Registry information

Official study title

The Effect of Alogliptin Combined With Pioglitazone and Metformin Hydrochloride Tablets on Glucose and Lipid Metabolism and Islet Function in Patients With Type 2 Diabetes Mellitus Complicated With Metabolic Dysfunction-associated Fatty Liver Disease

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Dec 17, 2025
Registry last updated
Mar 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.