Skip to main content
OpenTrials
Enrolling by Invitation

NCT Number: NCT07632911

THE EFFECT OF AEROBIC AND RESISTANCE TRAINING ON THE IMMUNE SYSTEM

Six-week exercise interventions in sedentary young women demonstrated that aerobic exercise and resistance exercise differentially optimize inflammatory and immune responses through their effects on osteocalcin and IgM, and IgA, respectively. These distinct effects of exercise modality on immune biomarkers can be utilized to design personalized exercise programs.

Enrolling by Invitation

Interested in participating?

Request Info

Key information

Conditions

Sedentary Behavior Behavior

Age range

18 year–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

İnönu University

Malatya, Turkey (Türkiye)

About this study

The effects of exercise on the immune system have been studied for many years. Regular physical activity is known to enhance the effectiveness of the immune system by modulating the inflammatory response. Regular exercise has been shown to increase individuals' physical fitness levels. Exercise is used in the prevention and treatment of various diseases. Consequently, a review of the literature reveals numerous studies indicating that regular exercise positively impacts an individual's health. Regular exercise positively affects all systems of the organism, including the immune system. Changes in the immune system after acute and chronic exercise differ. The effects of exercise on the immune system vary depending on the intensity of the exercise and the physical characteristics of the individuals. While light to moderate exercise strengthens the immune system, intense exercise can suppress it. The effects of exercise on the immune system have been the subject of much research in recent years. However, the effects of different types of exercise (aerobic and resistance training) on immune markers are still not fully understood. Inflammatory markers, particularly C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), play a critical role in assessing the effect of exercise on the immune system. In addition, immunoglobulins (IgA, IgG, IgM) are important biomarkers in evaluating the immune response. This study aims to investigate the chronic effects of a 4-week aerobic and resistance exercise program on the immune system and inflammation. Blood and saliva samples will be collected and analyzed for CRP, IL-6, TNF-α, and immunoglobulin levels. The data obtained will help us understand the specific effects of different types of exercise on inflammatory and immune responses, contributing to more informed exercise prescriptions.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • University students aged 18-30
  • Individuals who have engaged in recreational exercise at least two days a week for the past three months
  • Those with low or no smoking or alcohol consumption who volunteer to participate in the study.

Exclusion criteria

  • Individuals who have had an infection or chronic illness in the last 6 months,
  • Those with a history of autoimmune disease,
  • Metabolic syndrome, or cardiovascular disease,
  • Those who have used antibiotics or anti-inflammatory drugs in the last 3 months,
  • Those who have suffered a serious injury during exercise or are unable to continue are not eligible.

Treatment and study plan

Aerobic and resistance exercise

Behavioral

Because it was done on young girls who lead a sedentary lifestyle.

Primary outcomes

  1. Change in C-Reactive Protein (CRP) Levels

    Time frame: Baseline (Week 0) and Post-intervention (Week 6)

    Serum C-reactive protein levels will be measured using an ELISA kit to evaluate systemic inflammation. (Unit of measurement: mg/L)

  2. Change in Interleukin-6 (IL-6) Levels

    Time frame: Baseline (Week 0) and Post-intervention (Week 6)

    Serum interleukin-6 levels will be analyzed to assess pro-inflammatory cytokine response. (Unit of measurement: pg/mL)

  3. Change in Tumor Necrosis Factor-Alpha (TNF-α) Levels

    Time frame: Baseline (Week 0) and Post-intervention (Week 6)

    Serum tumor necrosis factor-alpha levels will be measured to evaluate pro-inflammatory cytokine activity. (Unit of measurement: pg/mL)

  4. Change in Salivary Immunoglobulin A (IgA) Levels

    Time frame: Baseline (Week 0) and Post-intervention (Week 6)

    Salivary Immunoglobulin A levels will be measured to evaluate mucosal immune response. (Unit of measurement: mg/dL)

  5. Change in Immunoglobulin M (IgM) Levels

    Time frame: Baseline (Week 0) and Post-intervention (Week 6)

    Serum Immunoglobulin M levels will be measured to assess acute infection and humoral immune response. (Unit of measurement: mg/dL)

  6. Change in Immunoglobulin G (IgG) Levels

    Time frame: Baseline (Week 0) and Post-intervention (Week 6)

    Serum Immunoglobulin G levels will be measured to assess long-term immune memory and humoral immune response. (Unit of measurement: mg/dL)

  7. Change in Leukocyte (WBC) Count

    Time frame: Baseline (Week 0) and Post-intervention (Week 6)

    Total leukocyte (White Blood Cell) count will be analyzed to assess general immune and inflammatory status. (Unit of measurement: cells/µL)

Sponsors and collaborators

Lead sponsor

Inonu University

Other

Registry information

Official study title

AEROBİC AND RESİSTANCE TRAİNİNG EFFECTS ON INFLAMMATORY AND IMMUNE BİOMARKERS İN YOUNG SEDENTARY WOMEN

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 8, 2026
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.