The Effect of Administration of Low Dose Adrenaline During Surgery on Bleeding During Hip Surgery

Hip arthroplasty is associated with bleeding, anemia and the need for allogeneic transfusion. Administration of low-dose adrenaline activates the coagulation system and may decrease intraoperative and immediate postoperative bleeding. Thus, the aim of this study is to evaluation whether intraoperative IV-administration of low-dose adrenaline reduces bleeding in elective total hip arthroplasty.

Inclusion criteria

• Age > 18 years.
• Scheduled for primary unilateral hip arthroplasty
• Able to give consent

Exclusion criteria

• Allergy towards adrenaline
• Current treatment with: ADP receptor inhibitors or Vitamin K antagonists (within 5 days), Factor Xa inhibitors or Thrombin inhibitors (within 1 day), heparin (excluding low molecular weight heparin for perioperative thromboprophylaxis).
• Current treatment with tricyclic antidepressants
• Use of MAO inhibitors (within previous 14 days) or COMT inhibitors (within 2 days).
• Acute coronary syndrome / myocardial infarction within the previous 6 months.
• not willing to accept blood transfusion
• Participation in other clinical trial within previous 30 days
• Women of childbearing age (without menopause for at least 12 months)
• Glaucoma
• Pheochromocytoma
• Low serum K+ (< 3.0 mmol/L)
• Thyrotoxicosis
• Digoxin intoxication
• Alcohol og drug abuse (investigators judgement)