Institut Franco Européen de Chiropraxie
Ivry-sur-Seine, Val De Marne, 94220, France
NCT Number: NCT03273868
This study evaluates the effect of a single high-velocity low-amplitude spinal manipulation on both cardiovascular autonomic activity and pressure pain thresholds.
It is a cross-over study, thus each participant will undergo both interventions (spinal manipulation and sham manipulation). Both interventions will be separated by a 48 h wash-out period.
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Notify Me18 year–40 year
All sexes
Interventional
Not applicable
Ivry-sur-Seine, Val De Marne, 94220, France
Several systematic reviews have shown that spinal manipulations may have an immediate effect on autonomic nervous system activity (e.g. increase in skin sympathetic nerve activity) and on sensitivity to experimentally-induced pain (e.g. increase in pressure pain threshold).
It is generally unknown i) if these supposed effects last after the immediate post intervention period and ii) if there is a statistical relationship between them, considering that pain and autonomic networks are closely connected and interact at the peripheral, spinal and supra-spinal levels.
The primary aim of the study is to assess every single effect immediatly and at short-term after the intervention.
The secondary aim is to assess the bivariate statistical relationship between cardiovascular autonomic activity and sensitivity to experimentally-induced pain after the intervention.
Cardiovascular autonomic nervous system activity is assessed with both heart rate and systolic blood variabilities
Sensitivity to experimentally-induced pain is measured using pressure pain threshold.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
The researcher manually applies a preload force on the T5/T6 level followed by a single posterior to anterior thrust.
The researcher manually applies a preload force on the right scapula followed by a single lateral thrust.
Time frame: Baseline, + 5 minutes, + 15 minutes, + 30 minutes
Frequency and Time-domain analyses of HRV from 5-minutes ECG recording
Time frame: Baseline, immediatly after intervention, + 12 minutes, + 25 minutes, + 35 minutes
The mean of 3 successives PPT in kilopascal
Time frame: Baseline, + 5 minutes, + 15 minutes, + 30 minutes
Frequency analysis in the low frequency band of systolic blood pressure variability from 5-minutes recording
Institut Franco Europeen de Chiropratique
Other
The Effect of a Single Spinal Manipulation on Cardiovascular Autonomic Activity in Healthy Subjects: a Randomized, Cross-over, Sham-controlled Trial
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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