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OpenTrials
Completed

NCT Number: NCT06129513

The Effect of a Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis

Dietary protein ingestion is required to maximise the anabolic response during the recovery from resistance exercise. Whey protein is considered the optimal dietary strategy to maximise post-exercise muscle protein synthesis, but animal-protein production and consumption is associated with growing environmental and ethical concerns. Plant-based protein sources are considered of lesser anabolic quality than isonitrogenous boluses of animal-derived protein attributed to, at least in part, deficiencies in key essential amino acid. Blending different protein sources may overcome amino acid deficiencies and potentiate the post-exercise anabolic response. In the present study the investigators assessed the post-exercise muscle protein synthetic response following the ingestion of a novel plant-based protein isolate when compared with an isonitrogenous bolus of whey protein in healthy young, resistance trained women and men.

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Key information

Conditions

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Exeter

Exeter, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI between 18 - 30
  • Resistance trained (>3 times per week structured resistance exercise training for at least 3 months)

Exclusion criteria

  • Any metabolic impairment
  • Any cardiovascular impairment
  • Smoking
  • Lactose intolerance
  • Allergies to products containing dairy, meat or nuts
  • Prescribed intake of over the counter pharmaceuticals

Treatment and study plan

Bilateral resistance exercise

Behavioral

A bout of bilateral resistance exercise consisting of barbell back squat, leg leg press and leg extension

Whey Protein

Dietary Supplement

Following execution of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate

Plant-blend protein

Dietary Supplement

Following execution of bilateral resistance exercise, participants will ingest 32 g protein from plant-blend protein isolate

Primary outcomes

  1. Post-exercise myofibrillar protein synthesis following protein ingestion

    Time frame: 4 hours

    The fractional synthetic rate of myofibrillar proteins

Secondary outcomes

  1. Post-exercise myofibrillar protein synthesis during the early postprandial period

    Time frame: 2 hours

    The fractional synthetic rate of myofibrillar proteins

  2. Post-exercise myofibrillar protein synthesis during the late postprandial period

    Time frame: 2 hours

    The fractional synthetic rate of myofibrillar proteins

  3. Plasma amino acid response

    Time frame: 4 hours

    Post-exercise and postprandial change in plasma amino acid concentrations and availability

  4. Serum insulin response

    Time frame: 4 hours

    Post-exercise and postprandial change in serum insulin concentrations

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Registry information

Official study title

The Effect of a Novel Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis When Compared to Whey Protein in Healthy Young Adults

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Nov 13, 2023
Registry last updated
Nov 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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