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OpenTrials
Completed

NCT Number: NCT05641454

The Effect of a Peat and Apple Extract on Muscle ATP and Exercise Performance

A study to test the hypothesis that a combined peat and apple extract will increase blood and muscle ATP, which will increase cycling performance

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Key information

Conditions

Caffeine and Endurance Performance

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of Exeter

Exeter, Devon, EX1 2LU, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 - 40
  • Healthy
  • Recreationally active (i.e. Participants will be deemed as too trained if they are defined as participating in structured resistance exercise 3 or more times per week for >6 months or participating in structured endurance exercise for >6h per week for >6 months. Participants will be defined as too sedentary if they do not exceed the governments guidelines of 150 / 75 min per week of light / heavy exercise.)

Exclusion criteria

  • Allergy to Lidocaine
  • Any diagnosed metabolic health condition
  • Pregnant
  • Non-habitual caffeine intake
  • Smoker
  • Diagnosed Cardiovascular disease
  • Beta-Blockers
  • Recent history of musculoskeletal injury

Treatment and study plan

ElevATP supplement

Dietary Supplement

ElevATP supplement containing apple and ancient peat extract

Placebo

Dietary Supplement

Maltodextrin placebo

Primary outcomes

  1. Muscle ATP concentration

    Time frame: 4 hours

    Concentration of ATP in skeletal muscle tissue (mmol/kg dry weight)

Secondary outcomes

  1. Total work performed during exercise

    Time frame: 2 hours

    Work performed during glycogen depleting exercise on a cycle ergometer (J)

  2. Blood ATP concentration

    Time frame: 4 hours

    Concentration of ATP in blood (mmol/L)

  3. Substrate oxidation

    Time frame: 1 hour

    Substrate oxidation over 1 h steady state cycle (g/min)

  4. Blood glucose concentration

    Time frame: 4 hours

    Concentration of glucose in blood (mmol/L)

  5. Blood lactate concentration

    Time frame: 4 hours

    Concentration of lactate in blood (mmol/L)

  6. Muscle glycogen

    Time frame: 4 hours

    Muscle glycogen concentration in skeletal muscle tissue (mmol/kg dry weight)

  7. Muscle ADP concentration

    Time frame: 4 hours (mmol/kg dry weight)

    Concentration of muscle metabolites

  8. Muscle ATP concentration

    Time frame: 4 hours (mmol/kg dry weight)

    Concentration of muscle metabolites

  9. Muscle creatine concentration

    Time frame: 4 hours (mmol/kg dry weight)

    Concentration of muscle metabolites

  10. Muscle phosphocreatine concentration

    Time frame: 4 hours (mmol/kg dry weight)

    Concentration of muscle metabolites

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Collaborators

  • VDF FutureCeuticals Inc.

Registry information

Acronym: APEX

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Dec 7, 2022
Registry last updated
Mar 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.