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OpenTrials
Completed

NCT Number: NCT01914822

The Effect Methylphenidate Hydrochloride on Pain and Auditory Sensitivity in Healthy Subjects

1. To examine whether Ritalin has analgesic properties in healthy subjects. 2. To examine if Ritalin analgesic effect is a pain specific phenomenon or a part of a broader, non-specific effect on high mental functions.

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Key information

Conditions

Pharmacological Action (PA)

Age range

20 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 2

Primary location

Rambam Healthcare Campus

Haifa, 31096, Israel

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male subjects between the ages of 20 to 40
  • Healthy subjects without known disease and without any chronic pain
  • Subjects without known cognitive problems, which can understand the research and its goals
  • Subjects who are not taking any medications
  • Subjects without hearing problems
  • Subjects without attention deficit disorder (ADHD) problems

Exclusion criteria

  • Subjects who are known to suffer from any disease or any chronic pain
  • Subjects taking psychotropic drugs (except Ritalin) or any analgesics
  • Subjects who have any contradictions for ritalin administration
  • subjects with suspected cognitive disability

Treatment and study plan

Methylphenidate Hydrochloride

Drug

Sugar Pill (placebo)

Drug

Primary outcomes

  1. Experimental pain intensity measured on a visual analogue scale (0-100)

    Time frame: 4 hours

Secondary outcomes

  1. effect of Ritalin on auditory sensitivity, measured by the response to different auditory stimulations

    Time frame: 4 hours

  2. pain intensity (NPS 0-100) in response to thermal stimuli and the measures of the auditory tests.

    Time frame: 4 hours

Sponsors and collaborators

Lead sponsor

Rambam Health Care Campus

Other

Registry information

Official study title

The Effect of Ritalin (Methylphenidate Hydrochloride) on Pain and Auditory Sensitivity: an Exploratory Double-blind Randomized Controlled Trial on Healthy Subjects

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Aug 2, 2013
Registry last updated
Sep 12, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.