The Effect and Mechanisms of the Second-meal Phenomenon in Type 2 Diabetic Patients

Second-meal phenomenon denotes the effect of a prior meal in decreasing the rise in blood glucose after a subsequent meal. This phenomenon occurs in normal subjects while it is not clear whether it is also observed in type 2 diabetic patients. This study aims to define whether the second-meal phenomenon occurs in type 2 diabetic patients. We will also seek for the mechanism.

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Key information

Conditions

Type 2 Diabetes Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

35 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

St. Vincent's hospital

Suwon, Kyounggi-do, 442-723, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age 35-70
HbA1c 6-8%
DM duration less than 5 yrs

Exclusion criteria

type 1 DM, secondary DM, gestational DM
patients using insulin, TZDs
patients using corticosteroid, herb medication or other medications affecting glucose tolerance
renal dysfunction (Cr > 1.5mg/dL)
hepatic dysfunction (LFT > x 3UNL)
anemia (Hg < 10g/dL)
ischemic heart disease, congestive heart failure
severe diabetic complication (CRF, CVA, PDR, gastroparesis)
infectious disease
malignancy
pregnant women

Treatment and study plan

Primary outcomes

Area under the curve of plasma glucose after meal

Time frame: 3 months

Compare the post-lunch AUC of glucose between two meal tolerance tests(one after having breakfast, one after not having breakfast)

Secondary outcomes

the mechanism of second-meal phenomenon

Time frame: 3 months

serum FFA, plasma insulin, C-peptide, incretin concentration will be measured

Sponsors and collaborators

Lead sponsor

The Catholic University of Korea

Other

Registry information

Official study title

The Effect and Mechanisms of the Second-meal Phenomenon in Type 2 Diabetic

Important dates

Study start: 2010
Primary completion: 2010
Study completion: 2010
First posted: May 21, 2010
Registry last updated: Aug 23, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed