The Diagnostic Value of Subharmonic Imaging Technology Combined With Liver Stiffness and Platelet Count for High-risk Esophageal and Gastric Varices in Patients With Liver Cirrhosis

Primary outcomes

1. HV-PV (dB)

   Time frame: Within two weeks of admission

   The difference in the average harmonic signal between the hepatic vein and the portal vein

2. Measurement of liver stiffness（kPa）

   Time frame: Within two weeks of admission

   The patient lies on their back, with their right hand placed behind their head. The right upper limb is fully abducted to expose the intercostal Spaces in the right lobe of the liver. The area usually enclosed by the horizontal line of the xiphoid process, the midline of the right axilla and the lower edge of the rib is taken as the testing area. The probe is vertically and closely attached to the skin, and the measurement position is selected in the intercostal space.

3. blood platelet count（×10⁹／L）

   Time frame: Within two weeks of admission

   The peripheral blood of the patient was tested by a conventional blood analyzer to obtain the platelet count.

4. sensitivity and specificity

   Time frame: The one-year period from enrollment to the end of the group

   The sensitivity measures the ability of the model to correctly identify patients with HRV (i.e., the true positive rate), and the specificity measures the ability of the model to correctly exclude patients without HRV (i.e., the true negative rate).

5. Positive predictive value (PPV) and negative predictive value (NPV)

   Time frame: The one-year period from enrollment to the end of the group

   PPV represents the probability that patients identified as high-risk by the model actually have HRV, while NPV represents the probability that patients identified as low-risk by the model do not actually have HRV

6. AUC

   Time frame: The one-year period from enrollment to the end of the group

   Comprehensively reflect the overall discriminative ability of the model under different thresholds