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Completed

NCT Number: NCT02697760

The CZT Dynamic Myocardial Perfusion Imaging

To develop and validate the noninvasive measurement of MBF and MFR by using dynamic imaging with a CZT camera, and evaluate the diagnostic and prognostic implications in various heart disease.

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Key information

Conditions

Cardiac Disease Cardiovascular Diseases Heart Diseases

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Far Eastern Memorial Hospital

New Taipei City, 220, Taiwan

About this study

Absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR) provide incremental diagnostic and prognostic information over relative perfusion alone. Recent development of dedicated cardiac SPECT cameras with better sensitivity and temporal resolution make dynamic SPECT imaging more practical. The potential roles of myocardial perfusion in subjects with cardiovascular risks and heart failure warrant further investigations.

The present project aims to develop and validate the noninvasive measurement of MBF and MFR by using dynamic imaging with a CZT camera, and evaluate the diagnostic and prognostic implications.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Coronary heart disease
  • Clinical diagnosis of heart failure
  • Clinical diagnosis of metabolic diseases (such as metabolic syndrome, obesity, diabetes, hyperlipidemia, micro vascular diseases, etc.), heart failure or coronary heart disease in high-risk groups persons.

Exclusion criteria

Significant systemic disease (except heart disease) such as cirrhosis, end-stage renal disease or active malignancy, estimated life expectancy of less than three months, persons; pregnant or lactating women have the possibility of pregnancy.

Treatment and study plan

thallium-201

Radiation

Thallium (Tl-201) myocardial single photon emission tomography, dynamic imaging

Primary outcomes

  1. Coronary artery disease (CAD) diagnosis

    Time frame: 12 months after the index MPI

    CAD defined as more than 50% stenosis in any vessel by coronary angiography or computed tomography.

Secondary outcomes

  1. MACE (major adverse cardiac events)

    Time frame: 5 years after the index MPI

    revascularization, acute myocardial infarction, hospitalization for heart failure, cardiac death, non-cardiac death

Sponsors and collaborators

Lead sponsor

Far Eastern Memorial Hospital

Other

Registry information

Official study title

The Quantification, Clinical Application of Dynamic Imaging Using Cadmium-zinc-telluride (CZT) Cameras to Assess Myocardial Perfusion

Acronym: CZT

Important dates

Study start
2015
Primary completion
2018
Study completion
2022
First posted
Mar 3, 2016
Registry last updated
Oct 24, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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