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Completed

NCT Number: NCT01344265

The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume

The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.

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Key information

Conditions

Critically Ill Critical Illness Disease Attributes Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Jinhua central hospital

Jinhua, Zhejiang, 321000, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • critically ill patients who required hemodynamic monitoring using PiCCO

Exclusion criteria

  • patients with renal dysfunction
  • those older than 80 years
  • pregnant women

Treatment and study plan

Primary outcomes

  1. global end diastolic volume

    Time frame: within 12 h after measurement of BNP

    this is measured by transpulmonary thermodilution technique

Sponsors and collaborators

Lead sponsor

Jinhua Central Hospital

Other

Registry information

Official study title

The Correlation Between BNP and Global End Diastolic Volume

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Apr 29, 2011
Registry last updated
Apr 4, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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