The Comparison of TACE-Lenvatinib With TACE-Lenvatinib-ablation for Intermediate Recurrent Hepatocellular Carcinoma

The evidence of ablation combined transarterial chemoembolisation (TACE) and Lenvatinib for intermediate-stage recurrent hepatocellular carcinoma (RHCC) is limited. Patient responses to this treatment vary because of the heterogeneous nature of RHCC. Thus, it is important to identify patients who are most likely to benefit from this three regimes therapy. The aim of this study is to comparison of TACE-Lenvatinib with TACE-Lenvatinib-ablation for intermediate RHCC.

Inclusion criteria

• 18-75 years;
• RHCC diagnosed by imaging;
• intermediate-stage RHCC (two to three lesions which at least one was >3 cm in size or more than three tumors);
• the tumor number was no more than six, and the maximum tumor diameter was ≤5 cm;
• absence of extrahepatic metastasis or macrovascular invasion;
• Child-Pugh class A or B;
• TACE as initial treatment after tumor recurrence and showed no tumor progression after TACE.
• life expectance >3 months;

Exclusion criteria

• under 18 years or over 75 years of age;
• primary intermediate-stage HCC;
• RHCC with more than six tumors, or single RHCC

(5) RHCC >5cm; (6) extrahepatic metastasis; (7) macrovascular tumor thrombus;