Skip to main content
OpenTrials
Completed

NCT Number: NCT03864276

The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Living Donor Liver Transplantation Under Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

Prolonged corrected QT interval (QTc) has been observed in about half of patients with liver cirrhosis. Marked prolongation of QTc (ie, 500 msec) has been considered to be a risk factor for fatal ventricular arrhythmia, such as torsade de pointes,7,8 which has been reported in liver transplantation (LT) surgery. In a previous study, prolonged QTc interval ( 500 msec) was frequently observed throughout the procedure of LT, even among patients with baseline QTc 440 msec. Therefore, it is important to optimize electrolyte balance and hemodynamic status to reduce greater risk of perioperative arrhythmias.

The investigators hypothesized that the change of QTc interval might be differ according to method of general anesthesia (inhalation agent vs. intravenous agent).

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Liver Cirrhosis(Who Will Undergo Planed Liver Transplantation)

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine

Seoul, 120-752, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with liver cirrhosis who will undergo planned liver transplantation

Exclusion criteria

  • 1. emergent liver transplantation
  • 2. unstable angina
  • 3. recent MI(Myocardial Infarction)
  • 4. uncontrolled hypertension (diastolic BP > 110mmHg)
  • 5. implantable cardiac defibrillator
  • 6. severe obesity (BMI>30kg/m2)
  • 7. allergy to propofol

Treatment and study plan

inhalation (desflurane) group

Drug

Anesthesia is induced and maintained with desflurane and sufentanil

total intravenous (propofol) anesthesia

Drug

Anesthesia is induced and maintained with propofol and sufentanil

Primary outcomes

  1. QTc interval

    Time frame: 3 minutes after liver reperfusion

    The investigator will assess the QTc interval 3 minutes after the reperfusion during liver transplantation.

Secondary outcomes

  1. QTc interval

    Time frame: at the end of the surgery

    The investigator will assess the QTc interval at the end of liver transplantation.

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Mar 6, 2019
Registry last updated
Oct 15, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.