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OpenTrials
Completed

NCT Number: NCT01318746

The Circadian Rhythm of Potassium and Cystatin C

The potassium value is important to prevent cardiac arrhythmias and sudden cardiac death. In patients with renal failure, the potassium value is not stable and tends to raise. Until now there are no data available if the potassium value has a circadian rhythm and if there are individual changes from day to day.

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Key information

Conditions

Cardiac Arrhythmias Arrhythmias, Cardiac Cardiovascular Diseases Death Death, Sudden Death, Sudden, Cardiac Heart Arrest Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Sudden Cardiac Death

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg

Erlangen, 91054, Germany

About this study

Potassium and cystatin c is measured every 2 hours during 24 hours, twice. There are two groups of patients: Patients with eGFR < 60 ml/min and patients with eGFR > 60 ml/min

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • at least 18 years old
  • normal renal function and impaired renal function (GFR < 60 ml/min) respectively

Exclusion criteria

  • pregnancy
  • anaemia (Hb<10 mg/dl)

Treatment and study plan

Blood withdrawal

Procedure

blood withdrawal every 2 hours during 24 hours

Primary outcomes

  1. Potassium rhythm

    Time frame: twice in 24 hours

    15 persons with normal renal function are hospitalized for 24 hours. Blood samples are taken every 2 hours in order to investigate the potassium value.

    It is repeated with 5 persons after 2 days, with 5 persons after 4 and with 5 persons after 6 days.

Secondary outcomes

  1. Potassium value in renal failure

    Time frame: twice in 24 hours

    15 persons with renal failure (GFR < 60 ml/min) are hospitalized for 24 hours. Blood samples are taken every 2 hours in order to investigate the potassium value It is repeated with 5 persons after 2 days, with 5 persons after 4 and with 5 persons after 6 days.

Sponsors and collaborators

Lead sponsor

University of Erlangen-Nürnberg Medical School

Other

Collaborators

  • Biotronik SE & Co. KG

Registry information

Official study title

The Circadian Rhythm of Potassium and Cystatin c and the Day-to-day Variability

Acronym: Potassium

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Mar 18, 2011
Registry last updated
Jan 12, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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