The Choice of a Violent Suicidal Means: a MRI Study With Computational Modeling of Decision-making

Inclusion criteria

• Right-handed (as assessed with the Edinburgh Handedness Scale).
• Agreement to participate and sign the informed consent form.
• Is insured or beneficiary of a health insurance plan.
• Speaks French.
• Suicide Attempters using Violent Means group:

• a personal history of mood disorder (bipolar disorder or depressive disorders according to DSM-5 criteria measured with the MINI 7.0);
• at least one suicidal act committed with a violent means within the last 5 years.
• Suicide Attempters using Non-Violent Means group:

• a personal history of mood disorder (bipolar disorder or depressive disorders according to DSM-5 criteria measured with the MINI 7.0);
• at least one suicidal act conducted within the last 5 years;
• no lifetime history of suicidal act with a violent means.
• Patient Control group:

• a personal history of mood disorder (bipolar disorder or depressive disorders according to DSM-5 criteria measured with the MINI 7.0);
• never attempted suicide in their lifetime;
• no family history of suicidal behavior up to the second biological degree.
• Healthy Control group:

• no personal history of major mental disorder according to the MINI 7.0;
• never attempted suicide in their lifetime;
• no family history of suicidal behavior up to the second biological degree.

Exclusion criteria

• Current participation or in the exclusion period of another research protocol in a category 1 RIPH
• Currently under judicial protection, or under adult guardianship.
• Refusal to participate.
• Is pregnant or breast feeding.
• The suicide attempt may have impacted the brain functioning (e.g. following hanging, asphyxia by drowning, head trauma following jumping from height, bullet impact, etc). This criteria will be assessed clinically by the investigator.
• Mental retardation (known or observed during the interview).
• Current psychotic disorder (according to the MINI 7.0).
• Current hypomanic episode (according to the MINI 7.0).
• Current manic, mixed, rapid cycling episodes (according to the MINI 7.0).
• Alcohol or substance disorder within last 3 months (according to the MINI 7.0).
• Past major brain trauma (with loss of consciousness > 1 minute).
• Contra-indication to MRI (metal in body (including due to suicidal act), claustrophobia, impossibility to lie still on the back during one hour).
• Electroconvulsive therapy within the last three months.