The Causative Insects in Severe Insect Sting Allergy

Study the causative insect by skin prick test and sIgE to wasp, bee and fire ants are important but false positive by crossreactivity can occur. sIgE to recombinant venom allergen is proposed to help in finding the causative insect.

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Key information

Conditions

Insect Sting Allergy Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Venom Hypersensitivity

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Insect sting allergy from insects in Hymenoptera is not uncommon. The reaction maybe very severe and life threatening. To find the cause of insect sting allergy is important in prevention and specific treatment such as immunotherapy. The skin prick test and sIgE of these insects may have cross reactions so it is difficult to be interpreted.

The usage of sIgE recombinant venom allergen can benefit in separate cross reaction and dual allergy reaction.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Cases with severe insect sting allergy reactions

Exclusion criteria

Without other severe systemic diseases
Not pregnant or lactation

Treatment and study plan

Skin prick test

Other

Skin prick tests to local and imported insect sting allergen with different concentration are performed.

sIgE measurement

Other

sIgE levels to stinging insect allergen and their recombinant venom allergen are measured

Primary outcomes

Mean wheal diameters of skin prick test of local and imported insect allergens

Time frame: 12 months

Compare Mean wheal diameters of skin prick test of local and imported insect allergens at different concentrations

Secondary outcomes

specific IgE level to stinging insect allergen and recombinant venom allergens

Time frame: 12 months

compare skin prick test result and levels of specific IgE level to stinging insect allergen and recombinant venom allergens

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Official study title

Evaluating the Causative Insects in the Cases With Severe Insect Sting Allergy

Important dates

Study start: 2015
Primary completion: 2016
Study completion: 2016
First posted: May 6, 2016
Registry last updated: May 6, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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