The Cartilage and Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis

The knee pain status of the patients who are followed in the rheumatology special branch of the Physical Medicine and Rehabilitation Outpatient Clinic and who meet the inclusion criteria will be questioned. In patients with or without knee pain, the cartilage thickness measurement of the knee joint will be measured from 3 points by ultrasound. At the same time, Quadriceps and Hamstring muscle thickness measurements of the patients will be made from the midpoints where the muscle thickness is the highest. The physician who performed the ultrasonographic measurements of the knee pain status of the patients does not know.

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Key information

Conditions

Rheumatoid Arthritis Arthritis Arthritis, Rheumatoid Atrophy Autoimmune Diseases Cartilage Degeneration Connective Tissue Diseases Immune System Diseases Joint Diseases Knee Pain Chronic Muscle Loss Muscular Atrophy Musculoskeletal Diseases Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Rheumatic Diseases Signs and Symptoms Skin and Connective Tissue Diseases

Age range

30 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital

Istanbul, Turkey (Türkiye)

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Rheumatoid Arthritis > Diagnosed for 1 year
-Female gender
-The patient has been in remission or low disease activity for at least 3 months
-Be able to ambulatory
-No significant deformity in the lower extremity joints

Exclusion criteria

Patient with active arthritis or high disease activity

- Significant deformity of the lower extremity joints and inability to ambulate
-Pregnant patient
- Presence of malignancy
- Patient with a severe psychiatric disorder and difficulty in cooperation
- Presence of cardiovascular and pulmonary comorbidities that will prevent exercise
-Male gender

Treatment and study plan

Ultrasonographic Measurements

Diagnostic Test

In patients with or without knee pain, the cartilage thickness measurement of the knee joint will be measured from 3 points by ultrasound. At the same time, Quadriceps and Hamstring muscle thickness measurements of the patients will be made from the midpoints where the muscle thickness is the highest.

Primary outcomes

Ultrasonographic Cartilage Thickness Measurement

Time frame: through study completion, an average of 1 month

Tibial cartilage thickness will be visualized by ultrasound with the knee held in 30 degrees of flexion, and 3 measurements will be taken from the medial, lateral and midline.
Ultrasonographic Muscle Measurement Thickness Measurement

Time frame: through study completion, an average of 1 month

The quadriceps muscle thickness will be measured by determining the midpoint between the SIAS and the patella while the patient is lying in the supine position. Hamstring muscle thickness will be measured at the intersection of a line drawn at 60% distal between the greater trochanter and the outer femoral condyle, and at the midline of the popliteal fossa, with the patient lying on the prone. These 2 measurements will be proportional to each other.

Sponsors and collaborators

Lead sponsor

Sisli Hamidiye Etfal Training and Research Hospital

Other

Registry information

Official study title

The Effect of Ultrasonographic Cartilage Thickness and Quadriceps/Hamstring Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis

Important dates

Study start: 2023
Primary completion: 2023
Study completion: 2023
First posted: Aug 21, 2023
Registry last updated: Nov 21, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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