Skip to main content
OpenTrials
Completed

NCT Number: NCT00774514

The Cardiovascular Effects of Nitrogen Dioxide Exposure

Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived particulate matter derived from traffic sources. It has been demonstrated that inhalation of diesel exhaust impairs vascular vasomotor tone and endogenous fibrinolysis. Recent studies using an inline retrofit particle trap to reduce the particulate component of exhaust have shown that filtering particles leads to a reversal of the endothelial dysfunction seen after diesel exhaust exposure, and have even suggested an augmentation of vascular function. This raises the question of the cardiovascular effects of the gaseous pollutants, the most abundant of which is nitrogen dioxide. In this study we plan to investigate the cardiovascular effects of nitrogen dioxide exposure.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Endothelial Dysfunction

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Umeå University

Umeå, Sweden

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy male volunteers

Exclusion criteria

  • Current smokers
  • Significant occupational exposure to air pollution
  • Regular medication use
  • Intercurrent illness

Treatment and study plan

Forearm Vascular Study

Procedure

Forearm venous occlusion plethysmography to measure forearm blood flow during intrabrachial infusion of vasodilators Acetylcholine (5-20 mg/min), sodium nitroprusside (2-8 µg/min), bradykinin (100-1000 pmol/min) and verapamil (10-100 µg/min)

Other names: ACh, SNP, BK

Primary outcomes

  1. Forearm blood flow measured by venous occlusion plethysmography in response to intraarterial vasodilators (acetylcholine, sodium nitroprusside, bradykinin and verapamil)

    Time frame: 4-6 hours after exposure

Secondary outcomes

  1. Plasma t-PA concentrations after infusion of bradykinin

    Time frame: During forearm study

  2. Exhaled nitric oxide

    Time frame: 4-6 hours after exposure

Sponsors and collaborators

Lead sponsor

University of Edinburgh

Other

Collaborators

  • Umeå University

Registry information

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Oct 17, 2008
Registry last updated
Apr 9, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.