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OpenTrials
Completed

NCT Number: NCT00809432

The Cardiovascular Benefits of Reducing Personal Exposure to Air Pollution

Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and myocardial ischaemia. The study objectives were to assess the potential cardiovascular benefits of reducing personal particulate air pollution exposure by wearing a facemask in healthy volunteers.

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Key information

Conditions

Blood Pressure Heart Rate Variability

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Medical Union College

Beijing, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers

Exclusion criteria

  • Current smokers
  • Significant occupational exposure to air pollution
  • Regular medication use (except oral contraceptive pill)
  • Intercurrent illness

Treatment and study plan

Face mask (Dust Respirator)

Device

Subjects to wear a simple face mask for 24 hours prior to the study day and the 24 hours of the study day. They will be instructed to wear the mask as much as possible when indoors and at all times when outdoors.

Other names: 3M Dust Respirator 8812

No Face mask

Other

Subjects will not wear a face mask to reduce their personal exposure to air pollution

Primary outcomes

  1. Ambulatory blood pressure

    Time frame: During 24 hour study period

Secondary outcomes

  1. Heart rate

    Time frame: During 24 hour study period

  2. Heart rate variability

    Time frame: During 24 hour study period

  3. Personal air pollution exposure

    Time frame: During 2 hour city centre walk

Sponsors and collaborators

Lead sponsor

University of Edinburgh

Other

Collaborators

  • Peking Union Medical College

Registry information

Official study title

Beneficial Cardiovascular Effects of Reducing Exposure to Particulate Air Pollution With a Simple Facemask

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Dec 17, 2008
Registry last updated
Dec 17, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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