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Completed

NCT Number: NCT03851419

The Burden of (Neuro)Cysticercosis Among People Living With HIV in Rural Tanzania

This study aims to compare the burden of neurocysticercosis among people living with HIV to people not infected with HIV.

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Key information

Conditions

Neurocysticercosis Acquired Immunodeficiency Syndrome Blood-Borne Infections Central Nervous System Diseases Central Nervous System Helminthiasis Central Nervous System Infections Central Nervous System Parasitic Infections Cestode Infections Communicable Diseases Cysticercosis Genital Diseases HIV Infections HIV/AIDS Helminthiasis Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections Nervous System Diseases Parasitic Diseases RNA Virus Infections Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Slow Virus Diseases Taeniasis Urogenital Diseases Virus Diseases

Age range

14 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

National Institute of Medical Research

Dar es Salaam, Tanzania

About this study

People living with HIV and matched HIV negative controls will be tested serologically for cysticercosis, examined neurologically and will undergo CT scanning to determine the prevalence and presentation of NCC.

Furthermore, the immune system response in HIV patients with Taenia solium neurocysticercosis will be assessed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who consent to participate in the study and testing.
  • Patients of age 14 years and above
  • Patient living inside the study catchment area
  • HIV-positive patients
  • Patient suspected of taeniasis or cysticercosis/neurocysticercosis

Exclusion criteria

  • Patients with opportunistic infections.
  • Study participants taking anthelminthic drugs PZQ and ALB or have received them within the previous 12 months.
  • Pregnant women
  • Patients that are seriously ill.
  • Patients with epilepsy and other mental disorders that impair thoughts and emotions such as psychosis.

Treatment and study plan

Diagnosis of (Neuro)cysticercosis

Diagnostic Test
  • Serological tests for cysticercosis
  • Neurological examination and cerebral CT scan for the diagnosis of neurocysticercosis
  • Stool testing for T. solium

Primary outcomes

  1. Prevalence of cysticercosis

    Time frame: Single assessment at inclusion into study (serological testing)

    Prevalence of cysticercosis among people living with HIV and matched HIV-negative individuals in rural Tanzania where pig farming is common

  2. Prevalence of neurocysticercosis

    Time frame: Single assessment through cerebral CT scan at inclusion into study

    Prevalence of neurocysticercosis among people living with HIV and matched HIV-negative individuals in rural Tanzania where pig farming is common

Secondary outcomes

  1. Th1 cytokines among neurocysticercosis patients

    Time frame: One time assessment through immunological testing at inclusion into study

    To compare the specific peripheral immune response against T. solium neurocysticercosis between symptomatic and asymptomatic patients measured by concentration of Th1 cytokines.

Sponsors and collaborators

Lead sponsor

Technical University of Munich

Other

Collaborators

  • Kilimanjaro Clinical Research Institute
  • Muhimbili University of Health and Allied Sciences
  • National Institute for Medical Research, Tanzania

Registry information

Official study title

The Burden of (Neuro)Cysticercosis Among People Living With HIV Compared With HIV-negative Individuals in the Rural Southern Highlands in Tanzania

Acronym: CYSTINET_Tz

Important dates

Study start
2018
Primary completion
2021
Study completion
2021
First posted
Feb 22, 2019
Registry last updated
Nov 29, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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