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Completed

NCT Number: NCT04868929

The Brain Activation During Different Motor Patterns in Healthy Adults

This study aims to investigate the brain activation during different motor patterns, including motor execution (ME), motor imagery (MI), action observation (AO) and mirror visual feedback (MVF). In addition, the relations between brain activation and motor performance will also be explored. This study includes two parts, which are upper limb and lower limb part. While executing all the tasks, brain activation in primary motor cortex(M1), premotor cortex(PMC), and supplementary motor cortex(SMA) will be monitored by functional near-infrared spectroscopy. One-way ANOVA with repeated measure will be used to detect the differences of brain activation level between each mode. Pearson correlation coefficient will be used to determine the relations of brain activation and motor performance.

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Key information

Conditions

Neurosciences

Age range

20 year–30 year

Sex eligibility

All sexes

Study type

Observational

Primary location

National Taiwan University Hospital

Taipei, Taiwan

About this study

In upper limb part, subjects will be instructed to execute functional reaching task in ME, MI, AO, and MVF mode. During ME mode, motor performance including maximum speed, maximum acceleration, and jerk will be collected simultaneously. In the lower limb part, subjects will be instructed to walking over ground in ME, MI, and AO mode. During ME mode, the temporal and spatial gait parameters, including speed, stride time, cadence, and stride length will be collected.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

  • Inclusion Criteria
  • Age between 20 to 30 years.
  • Right-handed.
  • Ability to walk 30 meters independently without an assistive device.
  • No neurogical, cardiopulmonary, or muscle diseases that might interfere with the experiment.
  • Mini-Mental State Examination (MMSE) score greater than 24.
  • Exclusion Criteria 1. Physiological condition is unstable.

Treatment and study plan

Primary outcomes

  1. Brain activities over primary motor cortex

    Time frame: Day 1

    A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.

  2. Brain activities over premotor cortex

    Time frame: Day 1

    A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.

  3. Brain activities over supplementary motor area

    Time frame: Day 1

    A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.

Secondary outcomes

  1. Motor performance of upper limb -maximum speed

    Time frame: Day 1

    cm/s

  2. Motor performance of upper limb -maximum acceleration

    Time frame: Day 1

    cm/s^2

  3. Motor performance of upper limb - jerk

    Time frame: Day 1

    cm/s^3

  4. Motor performance of lower limb - gait speed

    Time frame: Day 1

    cm/s

  5. Motor performance of lower limb - cadence

    Time frame: Day 1

    steps

  6. Motor performance of lower limb - stride time

    Time frame: Day 1

    second

  7. Motor performance of lower limb - stride length

    Time frame: Day 1

    cm

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Official study title

The Brain Activation During Motor Execution, Motor Imagery, Action Observation, and Mirror Visual Feedback in Healthy Adults

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
May 3, 2021
Registry last updated
Feb 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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