Skip to main content
OpenTrials
Recruiting

NCT Number: NCT05802706

The Biomechanical Study of Diseased Human Carotid, Femoral and Abdominal Aortic Tissue

This cross-sectional study aims to ascertain the mechanical properties of human carotid/femoral atherosclerotic plaque and abdominal aortic aneurysm tissue and correlate tissue mechanics with novel blood-based biomarkers of cardiovascular calcification.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Vascular Diseases Cardiovascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Limerick

Limerick, Ireland

Location status: Recruiting

Location contact

Fiona Leahy, MSc

CONTACT

[email protected]

061 301111

About this study

The study is a non-randomised, controlled, cross-sectional study of diseased human carotid, femoral and abdominal aortic tissue.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with arterial plaque undergoing treatment where the plaque tissue will be surgically removed as per the usual peripheral endarterectomy procedure.
  • Able to provide informed consent.

Exclusion criteria

  • Patients that are unable to give informed consent.
  • Seriously ill/unconscious patients.

Treatment and study plan

No intervention.

Other

No intervention.

Primary outcomes

  1. Calcification feature classification

    Time frame: 10 years

    Identification of particular calcification features of plaque tissue and their influence on mechanical properties which may help clarify the success of stenting in certain patient cohorts compared to others and elucidate the procedural risk of endovascular treatments in plaque with certain calcification types.

  2. Biomarker Analysis

    Time frame: 10 years

    Identification of novel biomarkers of vascular calcification could potentially be used as a predictive tool to highlight those at greatest risk of adverse peri-operative events, to allow for tailored medical treatment approaches and to stream-line patient care and improve patient outcomes.

Secondary outcomes

  1. Cardiovascular Health Critical Mass

    Time frame: 10 years

    To build a critical mass in cardiovascular health, an area of strategic importance for healthcare in Ireland.

Study contacts

Contact information is provided by the study sponsor or research team.

Fiona Leahy, MSc

CONTACT

[email protected]

061 301111

Sponsors and collaborators

Lead sponsor

University Hospital of Limerick

Other

Registry information

Important dates

Study start
2016
Primary completion
2027
Study completion
2027
First posted
Apr 6, 2023
Registry last updated
Apr 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.