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Completed

NCT Number: NCT02434185

The Bilateral Deficit Phenomenon, Functional and Dynamometric Assessment in Postmenopausal Women

The bilateral deficit phenomenon (BLD) is defined as an inability of the neuromuscular system to generate maximal force when two homonymous limb operate simultaneously (bilateral contraction) with respect to the force developed when both limbs acts separately (unilateral contraction). From an applied perspective, movement patterns of bilateral homonymous limb are often developed during activities of day living, e.g. rising from a chair or opening a jar. The BLD can be considered an intrinsic property of the human neuromuscular system but could be enough important to constitute a performance-limiting factor for postmenopausal women that involves a degenerative loss of muscular strength. Therefore, a specific analysis of this phenomenon and its relation with activities of daily living, such as climbing a step and rising from a chair, is crucial for detecting variables of neuromuscular performance and develop strategies to minimize the loss of strength.

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Key information

Conditions

Postmenopausal Syndrome Muscle Weakness Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

50 year–70 year

Sex eligibility

Female

Study type

Observational

Primary location

Catholic University of Murcia

Murcia, 30107, Spain

About this study

  • 20 postmenopausal women unexperience in strength training or resistance training, without musculoskeletal, neurological diseases, and cardiovascular limiting-diseases were recruited.
  • Maximum strength of lower limbs during leg-press exercise was measured for future analysis.
  • The force-time curves were measured during climbing a step and rising from a chair.
  • A fragility phenotype test was applied to the subjects to determine frailty phenotype classification, including; weight loss of greater than 10 lbs in the past 12 months, maximal handgrip strength, time to walk 15-ft at usual pace, self-reported leisure time physical activity, and self-reported exhaustion.
  • The anthropometric measurements were performed by dual energy X-ray absorptiometry.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Postmenopausal women

Exclusion criteria

  • Unexperienced in strength training or resistance training.
  • Not musculoskeletal diseases.
  • Not neurological diseases.
  • Not cardiovascular limiting-diseases.
  • Not fragility or pre-fragility phenotype.

Treatment and study plan

Primary outcomes

  1. Assess the maximum force of lower limbs during bilateral and unilateral contraction

    Time frame: Screening visit

  2. Assess the force-time curve during climbing a step

    Time frame: Screening visit

  3. Assess the force-time curve during climbing rising from a chair

    Time frame: Screening visit

  4. Assess bone mineral-free lean tissue mass by dual energy X-ray absorptiometry

    Time frame: Screening visit

  5. Assess the fragility phenotype of the subjects

    Time frame: Screening visit

  6. Assess the rate of force developed in time intervals (0-50, 50-100, 100-150ms) of lower limbs during bilateral and unilateral contraction

    Time frame: Screening visit

  7. Assess fat-tissue mass and lean-tissue mass composition

    Time frame: Screening visit

Sponsors and collaborators

Lead sponsor

Universidad Católica San Antonio de Murcia

Other

Registry information

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
May 5, 2015
Registry last updated
Oct 15, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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