The Rowett Institute
Aberdeen, AB25 2ZD, United Kingdom
NCT Number: NCT03077295
This weight loss study will investigate the impact of diet composition and meal size (large breakfast meals and smaller evening meals) on body weight, energy balance and eating behaviour, by altering calorie (meal) distribution.
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Notify Me20 year–60 year
All sexes
Interventional
Not applicable
Aberdeen, AB25 2ZD, United Kingdom
The aim of this study is to further strengthen our understanding of the role of dietary components (in particular fibre and protein) in a healthy diet. The information gained from this research will lead to better policy advice, particularly in relation to healthy weight management, metabolic control, mental health and intestinal health. It will also lay the foundations to produce healthier primary products and aid the food industry in developing new and healthier products (e.g. products that aid hunger control and satiety). This will be addressed through four interlinked objectives:
O1: Healthy weight management and improved metabolic and mental health O2: Identification of gut bacteria and compounds of relevance to vascular and gut health O3: Linking fibre consumption to intestinal microbial communities and health O4: Mathematical modelling of interactions between diet and gut microbial communities
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
High fibre/carbohydrate (50% CHO, 35% fat and 15% Protein) with 45% calories at breakfast and 20% evening meal provided and buffet lunch. Total dietary fibre will be at least 30g/d for 2000kcal intake and provided as a mixed soluble and insoluble fibre sources to maintain palatability of the diet (e.g. wheat bran, fava bean, lentil, buckwheat).
Other names: HF
Other names: HP
Time frame: measured up to day 71 of study
Chronic influence on energy balance (body weight, kg)
Time frame: Baseline & week 4 of each treatment
Appetite questionnaires recorded on Visual Analogue Scales every 30mins on test days
Time frame: Baseline & week 4 of each treatment
blood samples analysed for Glucose, Lipids and Hormones
Time frame: Baseline & week 4 of each treatment
gastric emptying (stable isotope, Octanoic acid labelled breath samples)
Time frame: Baseline & week 4 of each treatment
Chronic influence on metabolism or Thermic Effect of Food (TEF) using indirect calorimetry measurement
Time frame: up to 10 weeks
Chronic influence on changes in gut microbiota
Time frame: Baseline & week 4 of each treatment
Dual Energy X-ray Absorptiometry (DXA) Scan to measure fat mass, fat free mass & bone density as part of the 4 compartment model
Time frame: Baseline & week 4 of each treatment
Air Displacement Plethysmography (BodPod) to measure body fat as part of the 4 compartment model
Time frame: Baseline & week 4 of each treatment
Deuterium Dilution to measure Total Body Water (TBW) as part of the 4 compartment model
University of Aberdeen
Other
Role of Breakfast Size and Composition for Appetite Control and Energy Balance
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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