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OpenTrials
Completed

NCT Number: NCT04048213

The Becoming of Children With Doose Syndrome

Doose syndrome is a rare epileptic syndrome that can lead to learning difficulties and a poor quality of life. The goal of this study is to evaluate the evolution of epilepsy and its consequences on cognitive development and learning issues in children with Doose syndrome.

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Key information

Conditions

Doose Syndrome Brain Diseases Central Nervous System Diseases Communication Disorders Epilepsies, Myoclonic Epilepsy Epilepsy, Generalized Epileptic Syndromes Learning Disabilities Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurodevelopmental Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

1 year–6 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Amiens

Amiens, 80480, France

About this study

Doose syndrome is a rare epileptic syndrome beginning between ages two and five, characterized by myoclonic-astatic seizures which can be associated with myoclonic seizures, astatic seizures, absences and generalized tonic-clonic seizures. These seizures can be difficult to treat effectively and may lead to learning difficulties. During this study, parents of children with Doose syndrome will receive a questionnaire regarding learning disabilities, quality of life and epilepsy of their children.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • children with doose syndrome diagnosed between ages 1 and 6
  • normal development until onset of seizures

Exclusion criteria

  • unconfirmed diagnoses
  • abnormal diagnoses
  • abnormal psychomotor development before onset of seizures
  • cerebral MRI abnormalities
  • other child epileptic syndromes

Treatment and study plan

Questionnaire

Other

questionnaire send to the parents

Primary outcomes

  1. disease effects on the learning ability of children with doose syndrome

    Time frame: day of inclusion

    disease effects on the learning ability of children with doose syndrome base on scholar informations

Secondary outcomes

  1. Evolution of epilepsy in children with doose syndrome based on pathological symptoms

    Time frame: day of inclusion

    Evolution of epilepsy in children with doose syndrome based on pathological symptoms

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Collaborators

  • University Hospital, Lille
  • University Hospital, Rouen

Registry information

Acronym: DOOSE

Important dates

Study start
2019
Primary completion
2023
Study completion
2023
First posted
Aug 7, 2019
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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