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Completed

NCT Number: NCT01944878

The Association With Peptic Ulcer Disease and Hepatic Vein Pressure Gradient

The aim of this study is to assess the role of portal hypertension of peptic ulcer disease in liver cirrhosis and chronic hepatitis.

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Key information

Conditions

Cirrhosis Chronic Liver Disease Digestive System Diseases Duodenal Diseases Fibrosis Gastrointestinal Diseases Hypertension, Portal Intestinal Diseases Liver Cirrhosis Liver Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Peptic Ulcer Stomach Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chuncheon Sacred Heart hospital

Chuncheon, Gangwon-do, 200-704, South Korea

About this study

Retrospective case-control study

  • Investigators will analyze the medical records of hepatic vein pressure gradient (HVPG) and esophagogastroduodenoscopy (EGD) cases who had liver cirrhosis (LC) or chronic hepatitis in a single tertiary hospital (Chuncheon Sacred Heart hospital, Korea) within 2008~2012.
  • Portal hypertension is assessed using HVPG measurement via transjugular approach.
  • Peptic ulcer is evaluated through EGD within 3 months of HVPG measurement
  • The association of Peptic ulcer with LC, chronic hepatitis and total population (LC or chronic hepatitis) will be assessed by univariate and multivariate analysis
  • There is no specific time frame, because this study is retrospective observational study, however EGD data is enrolled if it was done within 3 month from HVPG measurement.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The patients who underwent hepatic vein pressure gradient (HVPG) measurement and esophagogastroduodenoscopy (EGD) and also had LC or chronic hepatitis

Exclusion criteria

  • The patients who have missing or incomplete HVPG or EGD data
  • The patients who underwent gastrectomy
  • The patients who have systemic malignancy

Treatment and study plan

Primary outcomes

  1. The Association of HVPG and PUD in Patients With Liver Cirrhosis

    Time frame: Retrospective case-control study (from 2009 to 2012, up to 3 years)

    The association of hepatic vein pressure gradient that reflects portal hypertension and peptic ulcer disease in patients with liver cirrhosis was assessed statistically.

    (NO specific time frame, only confined to 2009 to 2012, when the HVPG measurement was done). The Mann-Whitney test was used to evaluate the association between PUD or not and HVPG degree, by SPSS software.

Secondary outcomes

  1. The Association Between PUD and HVPG in Patients With Chronic Hepatitis

    Time frame: Retrospective case-control study (from 2009 to 2012, up to 3 years)

Sponsors and collaborators

Lead sponsor

Chuncheon Sacred Heart Hospital

Other

Registry information

Official study title

Retrospective Observational Study of Impact of Portal Hypertension for the Peptic Ulcer in Liver Cirrhosis and Chronic Hepatitis

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Sep 18, 2013
Registry last updated
Jul 24, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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