The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma

This study will investigate the changes and associations in asthma. In this project, the investigators will explore the changes of gene expression of transgelin-2, metallothionein-2 and ezrin in asthma and investigate their correlation with current diagnosis markers of asthma, including pulmonary function, fractional exhaled nitric oxide,eosinophil counts,immunoglobulin E, interleukin-5, etc.

Inclusion criteria

• Males or females, aged 14-75 years;
• Patients with a definite diagnosis of bronchial asthma;
• The diagnosis of asthma according to the Global Initiative for Asthma (GINA), with positive bronchodilator responsiveness (reversibility) test;
• Healthy volunteers without respiratory symptoms such as cough, wheezing, chest tightness or dyspnea;
• Agree with all procedures in this trial by signing a written informed consent form.

Exclusion criteria

• Patients with chronic obstructive pulmonary disease or other airway disease;
• Complicated with other severe primary diseases (including hypertension, cancer, hyperthyroidism, bronchiectasia, cardiac insufficiency) and conditions that would prevent participation in the trial or put the participant at risk;
• Women who are known to be pregnant or breastfeeding;
• Not willing to participate;
• Psychiatric history and neurological disorders can not work normally;
• Other conditions that the researcher considers inappropriate to participate in this study.