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OpenTrials
Completed

NCT Number: NCT02498938

The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders

Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing periodontitis.

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Key information

Conditions

Pulmonary Disease, Chronic Obstructive Chronic Disease Disease Attributes Generalized Chronic Periodontitis Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases

Age range

30 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Dr. Sneha Agarwal PG(periodontics)

Hyderabad, Telangana, 500034, India

About this study

periodontitis is a polymicrobial inflammatory disease caused by various modifiable and non-modifiable risk factors. the non-modifiable risk factors include genetic polymorphisms like the gene coding for alpha-1-antitrypsinase

COPD is a chronic inflammatory disease characterized by deterioration of lung function due to loss of elasticity of the lungs.

SERPINA1 gene product has a protective role on the connective tissue components of both lungs and gums.

Hence, this study tries to determine if the gene polymorphism in COPD serves as a risk factor for developing periodontitis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female patients aged between 30-70yrs diagnosed with COPD and chronic periodontitis who are willing to participate in the study.

Exclusion criteria

  • Pateints with other systemic disorders
  • patients not willing to participate in the study

Treatment and study plan

SERPINA1 gene

Genetic

2ml blood sample collected from patients to extract DNA for assessment of SERPINA1 gene polymorphism

Other names: serine peptidase inhibitor, proteinase inhibitor

Primary outcomes

  1. SERPINA1 gene polymorphism

    Time frame: 9 months

    of blood samples and running samples by PCR

Sponsors and collaborators

Lead sponsor

Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre

Other

Registry information

Official study title

Evaluation of SERPINA1 Gene Polymorphisms in COPD as a Risk Factor for Periodontitis

Acronym: SA1PLG

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Jul 15, 2015
Registry last updated
Aug 29, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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