the Association Between Obesity and Early Puberty

childhood obesity and early puberty are closely related, but existing reports usually focus on their relationship from the perspective of phenotype. This study was designed to investigate the association between obesity-related genic polymorphisms and the risk of early puberty in Chinese Han girls.

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Key information

Conditions

Early Puberty Endocrine System Diseases Gonadal Disorders Puberty, Precocious

Age range

7 year–10 year

Sex eligibility

Female

Study type

Observational

About this study

the genotypes of obesity-related SNPs were determined and the unstimulated luteinizing hormone, follicle stimulating hormone and estradiol levels were also detected.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion criteria

The participants who were not the first visit to the hospital and had been treated before.
The participants who were with endocrine disorders.

Treatment and study plan

Primary outcomes

genotypes of SNPs in the obesity-related genes

Time frame: 3 months

the obesity-related SNPs in the LRRN6C, MAF, CYP27A1 and ETV5 genes are selected and the genotypes of these SNPs are determined with a MassARRAY system.

Sponsors and collaborators

Lead sponsor

Shenzhen Center for Disease Control and Prevention

Other Gov

Registry information

Official study title

Polymorphisms in Obesity-related Genes Are Associated With Risk of Early Puberty in Han Chinese Girls

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2019
First posted: Mar 20, 2020
Registry last updated: Mar 20, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed