The Association Between Deep Endometriosis and the Occurrence of Colorectal Carcinoma

The goal of this study is to identify the molecular or genetic mechanisms that may predispose patients with bowel endometriosis to an increased risk of colorectal carcinoma. The study will include patients for whom surgical treatment of bowel endometriosis is clinically indicated.

This research would represent a significant advancement in evaluating the necessity of surgical intervention in asymptomatic patients or those with mild symptoms. Furthermore, it would provide a broader insight into the systemic impact of endometriosis on other organ systems, ultimately improving risk assessment and preventive measures.

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Key information

Conditions

Endometriosis Bowel Endometriosis Carcinogenesis Colon Resection Colonic Diseases Colorectal Carcinoma Colorectal Neoplasms Deep Endometriosis Digestive System Diseases Digestive System Neoplasms Endometriosis Pelvic Endometriosis Rectum Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Gastrointestinal Diseases Gastrointestinal Neoplasms Genetic Change Genital Diseases Genital Diseases, Female Infertility Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Neoplastic Processes Pathologic Processes Pathological Conditions, Signs and Symptoms Rectal Diseases Urogenital Diseases

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Female patients aged 18 and over, treated at the Department of Reproduction for diagnosed deep endometriosis, including bowel endometriosis, for whom surgical treatment is indicated.

Exclusion criteria

Patients with known inflammatory bowel disease (IBD), patients with a personal history of gynecological or gastrointestinal malignancy

Treatment and study plan

Primary outcomes

Comparison of gene expression in healthy and with endometriosis affected bowel.

Time frame: 3 years

Study contacts

Contact information is provided by the study sponsor or research team.

Rok Struna, MD

CONTACT

[email protected]

+38631441111

Sponsors and collaborators

Lead sponsor

University Medical Centre Ljubljana

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2028
Study completion: 2029
First posted: Feb 4, 2026
Registry last updated: Feb 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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