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Completed

NCT Number: NCT05919966

The Association Between Chlorhexidine Bathing and Central Line-Associated Infections in Medical Intensive Care Units

We conducted a retrospective observational cohort study assessing the relationship between regular bathing using 2% CHG wipes every other day and the occurrence of central line-associated infections (CLABSI) in patients within the medical intensive care unit (MICU).

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Key information

Conditions

Central Line-associated Bloodstream Infection (CLABSI)

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

National Taiwan University Hospital

Taipei, 100, Taiwan

About this study

This study defined the post-intervention period as July 1, 2017, to June 30, 2022. During this period, one of the three medical intensive care units (MICUs) in NTUH implemented chlorhexidine gluconate (CHG) bathing as part of their daily care routine (CHG group). This decision was made in response to a higher incidence rate of vancomycin-resistant Enterococcus (VRE) bacteremia observed in that particular MICU during the preceding six months (pre-intervention period: January 1, 2017, to June 30, 2017), compared to the other two MICUs. The remaining two MICUs continued to provide usual care, which involved bathing patients with towels soaked in water and soap on a daily basis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all patients who were admitted to the MICU between January 2017 and June 2022

Exclusion criteria

  • patients aged under 18 years old

Treatment and study plan

Chlorhexidine bathing

Other

The procedure involved pouring an entire bottle (200ml) of 2% CHG solution (PBF Biotech, Taipei, Taiwan) onto a pre-packed set of eight single-use cotton wipes before each bathing session. A minimum of six wipes were required to thoroughly cover the entire body, including the bilateral upper and lower extremities, front and back of the trunk, perineum, and buttocks.

Primary outcomes

  1. central line-associated bloodstream infections

    Time frame: Will be surveyed retrospectively through the study period (January 2017 to June 2022)

    the incidence rate of intensive care unit acquired central line-associated bloodstream infections

  2. multidrug-resistant organisms bacteremia

    Time frame: Will be surveyed retrospectively through the study period (January 2017 to June 2022)

    the incidence of CLABSIs with blood cultures positive for multidrug-resistant organisms

Secondary outcomes

  1. ICU length of stay

    Time frame: Will be surveyed retrospectively through the study period (January 2017 to June 2022)

    the total duration of the patient's ICU stay (days)

  2. hospital length of stay

    Time frame: Will be surveyed retrospectively through the study period (January 2017 to June 2022)

    the total duration of the patient's hospital stay (days)

  3. ICU mortality

    Time frame: Will be surveyed retrospectively through the study period (January 2017 to June 2022)

    whether the patient has died during their stay in the ICU

  4. hospital mortality

    Time frame: Will be surveyed retrospectively through the study period (January 2017 to June 2022)

    whether the patient has died during their stay in the hospital

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Official study title

The Association Between Chlorhexidine Bathing Every Other Day and Central Line-Associated Infections in Medical Intensive Care Units: An Observational Cohort Study

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jun 27, 2023
Registry last updated
Jun 27, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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