The Association Between Central Aortic Blood Pressure Indices and Severity of Coronary Artery Disease

Abstract

Objectives:

Primary: To study the association between central aortic blood pressure indices and coronary artery disease in patients undergoing elective angiography. Secondary: (a) To study whether any association exists between central aortic pressure indices and the incidence of major adverse cardiovascular events (MACE) in the same patients during a 6 month follow up period. (b) To study whether any association exists between the central aortic pressures and peripheral pressures.

Methods: The investigators conducted a prospective observational study in consecutive patients undergoing coronary angiography. Central and peripheral pressures were invasively recorded and coronary artery disease (CAD) classified into obstructive and non-obstructive group. CAD severity was graded using the Gensini score and subjects were divided into tertiles. Patients were followed up and the role of central aortic pressure indices in the prediction of cardiovascular events were analysed.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients undergoing elective angiography for diagnosis of CAD.
Age > 18 years

Exclusion criteria

Patients with acute myocardial infarction, unstable angina or thromboembolism in the preceding 3 months.
More than mild valvular heart disease.
Renal impairment with serum creatinine > 1.5 mg%.
Unable to obtain a full study of the coronary arteries.
Peripheral vascular occlusive disease.
Post coronary artery bypass grafting( CABG)
Heart rate < 50/min and > 120/min and other arrhythmias.
Contraindications for coronary angiography.
Unable to provide written informed consent

Treatment and study plan

CORONARY ANGIOGRAM AND CENTRAL AORTIC WAVEFORM ANALYSIS

Procedure

coronary angiogram

Primary outcomes

acute coronary syndrome(ACS)

Time frame: 6 MONTHS
stroke

Time frame: 6 months
revascularisation

Time frame: 6 months
death

Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Government Medical College, Kozhikode

Other

Registry information

Acronym: CAPCAD

Important dates

Study start: 2014
Primary completion: 2015
Study completion: 2015
First posted: Jun 15, 2015
Registry last updated: Jun 17, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed