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Completed

NCT Number: NCT04123028

The Association Between Blood Eosinophilsp in Thai COPD Patients: A Prospective Study

The association of blood eosinophil as a biomarker for eosinophilic Thai COPD patients, such as COPD exacerbation, hospital admission, lung functions and mortlity.

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Key information

Conditions

COPD Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of Medicine, Prince of Songkla university

Songkhla, 90110, Thailand

About this study

The prospective one year study in Thai COPD patients for the clinical outcomes of COPD compare between eosinophilic and non-eosinophilic which determine by blood eosinophil counts equal or more than 300 cells/microliters. The primary outcomes was COPD exacerbation, the secondary outcomes were lung function, dyspnea and quality of life.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of COPD by GOLD criteria

Exclusion criteria

  • high blood eosinophil from known causes such as systemic corticosteroid use, malignancy, parasitic infection
  • Patients who had previous acute exacerbation within 30-day before study entry
  • Patients who had previous systemic corticosteroids used within 30-day before study entry

Treatment and study plan

observatory

Other

observation for 1 year period

Other names: clinical outcomes

Primary outcomes

  1. Acute worsening of respiratory symptoms

    Time frame: 1 year

    acute severe worsening of respiratory symptoms

Secondary outcomes

  1. Physiological outcomes

    Time frame: 1 year

    Forced expiratory volume in one second

  2. health related quality of life

    Time frame: 1 year

    Chronic Obstructive Pulmonary Disease Assessment Test (CAT) scores which the minimum 0 and maximum 40 values, and whether higher scores mean a worse outcome.

Sponsors and collaborators

Lead sponsor

Prince of Songkla University

Other

Registry information

Official study title

The Association Between Blood Eosinophils and Clinical Outcomes of Chronic Obstructive Pulmonary Disease Patients: A Prospective Study

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Oct 10, 2019
Registry last updated
Oct 11, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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